Paraneoplastic neurological syndrome in a patient with gastric cancer

Paraneoplastic neurological syndromes (PNSs) are a heterogeneous group of neurological disorders caused by immunemediated mechanisms. The incidence of PNS is much less than 1% for solid tumors, except for small-cell lung cancer and thymoma. We report a rare case of gastric cancer that presented with...

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Bibliographic Details
Published in:Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2010-08, Vol.13 (3), p.204-208
Main Authors: Murakami, Hitoshi, Rino, Yasushi, Yamanaka, Shoji, Baba, Yasuhisa, Sekiguchi, Takashi, Yukawa, Norio, Oshima, Takashi, Sugano, Nobuhiro, Matsuura, Hitoshi, Masuda, Munetaka, Imada, Toshio
Format: Article
Language:English
Subjects:
Abdominal Surgery
Cancer Research
Case Report
Endocrine cell carcinoma
Female
Gastrectomy
Gastric cancer
Gastroenterology
Health Status Indicators
Humans
Immunohistochemistry
Medicine
Medicine & Public Health
Middle Aged
Oncology
Paraneoplastic neurological syndrome
Paraneoplastic Syndromes, Nervous System - diagnosis
Paraneoplastic Syndromes, Nervous System - etiology
Paraneoplastic Syndromes, Nervous System - pathology
Positron-Emission Tomography
Sensation Disorders - diagnosis
Sensation Disorders - etiology
Sensory disturbance
stomach neoplasms
Stomach Neoplasms - complications
Stomach Neoplasms - surgery
Surgical Oncology
Tomography, X-Ray Computed
United States
Vibration
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Summary:Paraneoplastic neurological syndromes (PNSs) are a heterogeneous group of neurological disorders caused by immunemediated mechanisms. The incidence of PNS is much less than 1% for solid tumors, except for small-cell lung cancer and thymoma. We report a rare case of gastric cancer that presented with primary clinical findings of PNS. The patient was a 63-year-old woman who was admitted for worsening neuropathy. Laboratory and neurological tests excluded a nutritional deficit, diabetes mellitus, and connective tissue disease as causes of her neuropathy. Computed tomography (CT) of the abdomen, positron emission tomography (PET)-CT, and endoscopy of the stomach revealed gastric cancer with lymph node swelling. Distal gastrectomy was performed and pathological and immunohistochemical examinations indicated endocrine cell carcinoma. The gastrectomy stopped the exacerbation of her symptoms and recurrence was not observed, but the neurological disorders were irreversible. This case suggests that early diagnosis of the primary tumor is required to improve the outcome in patients with PNS.
ISSN:1436-3291
1436-3305
DOI:10.1007/s10120-010-0563-2