Evaluation of the Antiobesity Effects of an Amino Acid Mixture and Conjugated Linoleic Acid on Exercising Healthy Overweight Humans: A Randomized, Double-blind, Placebo-controlled Trial

• Published in: Journal of international medical research 2010-05, Vol.38 (3), p.844-859
• Main Authors: Michishita, T, Kobayashi, S, Katsuya, T, Ogihara, T, Kawabuchi, K
• Format: Article
• Language: English
• Subjects: Adiposity; Adult; Aged; Amino Acids - administration & dosage; Body Mass Index; Body Weight; Double-Blind Method; Exercise; Female; Humans; Linoleic Acids, Conjugated - administration & dosage; Lipids - blood; Male; Middle Aged; Overweight - blood; Overweight - diet therapy; Overweight - physiopathology; Treatment Outcome; Waist Circumference; Waist-Hip Ratio; Young Adult
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/147323001003800311

This single-centre, randomized, double-blind, placebo-controlled trial investigated the effects of administering a mixture of four amino acids (lysine, proline, alanine and arginine) with or without conjugated linoleic acid to healthy overweight humans before and after exercising. Forty-one healthy subjects (body mass index ≥ 23 to < 30 kg/m2) completed the study following randomization to receive either placebo or one of three test supplements: amino acid mixture 0.76 g/day; amino acid mixture 1.52 g/day; or amino acid mixture 1.52 g/day coadministered with conjugated linoleic acid 1.6 g/day. Each of the study treatments was administered 30 min before and immediately after a period of daily exercise, which was delivered by an exercise expert, for a period of 12 weeks. When compared with the placebo group, several indicators, such as waist and hip circumferences, were found to have significantly decreased in the test supplement groups compared with the placebo. These results suggest that ingestion of these supplements might enhance the fat-burning effects of exercise.