The Beneficial Effect of n-3 Polyunsaturated Fatty Acids on Doxorubicin-induced Chronic Heart Failure in Rats

This study was designed to assess the effects of dietary supplementation with n-3 polyunsaturated fatty acids (PUFA) from fish oil on the response of doxorubicin-induced chronic heart failure in rats. Male Sprague–Dawley rats were treated daily for 8 weeks with normal saline or n-3 PUFA intragastric...

Full description

Saved in:
Bibliographic Details
Published in:Journal of international medical research 2010-06, Vol.38 (3), p.940-948
Main Authors: Teng, LL, Shao, L, Zhao, YT, Yu, X, Zhang, DF, Zhang, H
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - toxicity
Chronic Disease
Disease Models, Animal
Doxorubicin - toxicity
Echocardiography
Fatty Acids, Omega-3 - pharmacology
Heart - drug effects
Heart Failure - blood
Heart Failure - physiopathology
Heart Failure - prevention & control
Interleukin-10 - blood
Male
Myocardium - pathology
Rats
Rats, Sprague-Dawley
Tumor Necrosis Factor-alpha - blood
Ventricular Function - drug effects
Ventricular Function - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study was designed to assess the effects of dietary supplementation with n-3 polyunsaturated fatty acids (PUFA) from fish oil on the response of doxorubicin-induced chronic heart failure in rats. Male Sprague–Dawley rats were treated daily for 8 weeks with normal saline or n-3 PUFA intragastrically after induction of myocardial injury by intraperitoneal injection of doxorubicin 2 mg/kg once weekly for 8 weeks. Cardiac function was assessed by echocardiography. The cytoprotective role of n-3 PUFA against doxorubicin-induced myocardial injury was demonstrated by light microscopy, and serum cytokines (tumour necrosis factor-α and interleukin-10) were analysed by enzyme-linked immunosorbent assay. Doxorubicin induced death, alterations in echocardiography parameters and histological damage, all of which are features that characterize heart failure. There were significant differences between the doxorubicin-induced heart failure group and the n-3 PUFA-treated group in terms of echocardiography parameters and cytokine changes. Thus, dietary supplementation with n-3 PUFA attenuated doxorubicin-induced cardiac dysfunction, an effect that might be associated with recovery from an imbalance of the cytokine network.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323001003800320