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Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily

pqqD is one of six genes required for PQQ production in Klebsiella pneumoniae. Herein, we demonstrate that PqqD interacts specifically with the radical SAM enzyme PqqE, causing a perturbation in the electronic environment around the [4Fe-4S](+) clusters. This interaction redirects the role for PqqD...

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Published in:Chemical communications (Cambridge, England) England), 2010-10, Vol.46 (37), p.7031-7033
Main Authors: Wecksler, Stephen R, Stoll, Stefan, Iavarone, Anthony T, Imsand, Erin M, Tran, Ha, Britt, R David, Klinman, Judith P
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cited_by cdi_FETCH-LOGICAL-c352t-9bac27152673b143e741f7d18a26719ef81fc25c3d64599f6181db11a3d5789d3
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container_end_page 7033
container_issue 37
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container_title Chemical communications (Cambridge, England)
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creator Wecksler, Stephen R
Stoll, Stefan
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description pqqD is one of six genes required for PQQ production in Klebsiella pneumoniae. Herein, we demonstrate that PqqD interacts specifically with the radical SAM enzyme PqqE, causing a perturbation in the electronic environment around the [4Fe-4S](+) clusters. This interaction redirects the role for PqqD in PQQ biosynthesis.
doi_str_mv 10.1039/c0cc00968g
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source Royal Society of Chemistry Journals
subjects Bacterial Proteins - chemistry
Bacterial Proteins - metabolism
Free Radicals - chemistry
Free Radicals - metabolism
Klebsiella pneumoniae - enzymology
PQQ Cofactor - biosynthesis
PQQ Cofactor - chemistry
S-Adenosylmethionine - chemistry
S-Adenosylmethionine - metabolism
title Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily
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