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Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily
pqqD is one of six genes required for PQQ production in Klebsiella pneumoniae. Herein, we demonstrate that PqqD interacts specifically with the radical SAM enzyme PqqE, causing a perturbation in the electronic environment around the [4Fe-4S](+) clusters. This interaction redirects the role for PqqD...
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Published in: | Chemical communications (Cambridge, England) England), 2010-10, Vol.46 (37), p.7031-7033 |
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container_end_page | 7033 |
container_issue | 37 |
container_start_page | 7031 |
container_title | Chemical communications (Cambridge, England) |
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creator | Wecksler, Stephen R Stoll, Stefan Iavarone, Anthony T Imsand, Erin M Tran, Ha Britt, R David Klinman, Judith P |
description | pqqD is one of six genes required for PQQ production in Klebsiella pneumoniae. Herein, we demonstrate that PqqD interacts specifically with the radical SAM enzyme PqqE, causing a perturbation in the electronic environment around the [4Fe-4S](+) clusters. This interaction redirects the role for PqqD in PQQ biosynthesis. |
doi_str_mv | 10.1039/c0cc00968g |
format | article |
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source | Royal Society of Chemistry Journals |
subjects | Bacterial Proteins - chemistry Bacterial Proteins - metabolism Free Radicals - chemistry Free Radicals - metabolism Klebsiella pneumoniae - enzymology PQQ Cofactor - biosynthesis PQQ Cofactor - chemistry S-Adenosylmethionine - chemistry S-Adenosylmethionine - metabolism |
title | Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily |
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