Endothelial cells as targets for chylomicron remnants

• Published in: Atherosclerosis. Supplement (Amsterdam) 2010-06, Vol.11 (1), p.31-37
• Main Authors: Dalla-Riva, Jonathan, Garonna, Elena, Elliott, Jonathan, Botham, Kathleen M., Wheeler-Jones, Caroline P.
• Format: Article
• Language: English
• Subjects: Animals; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Blood vessels and receptors; Cardiology. Vascular system; Chylomicron remnants (CMRs); Chylomicron Remnants - metabolism; Endothelial cells; Endothelial Cells - immunology; Endothelial Cells - metabolism; Endothelial dysfunction; Endothelium, Vascular - immunology; Endothelium, Vascular - metabolism; Endothelium, Vascular - physiopathology; Fatty Acids - metabolism; Fundamental and applied biological sciences. Psychology; Humans; Inflammation - immunology; Inflammation - metabolism; Inflammation - physiopathology; Inflammation Mediators - metabolism; Medical sciences; Oxidative Stress; Triglyceride-rich lipoproteins (TGRLs); Vertebrates: cardiovascular system
• ISSN: 1567-5688; 1878-5050
• DOI: 10.1016/j.atherosclerosissup.2010.04.001

Endothelial dysfunction is characterised by pro-inflammatory/pro-coagulant changes in the endothelium and supports leukocyte adhesion and transmigration, key steps in early atherogenesis. There is emerging evidence that triacylglycerol-rich lipoproteins (TGRLs) present in the circulation during the postprandial phase influence vascular inflammation but the specific contribution of the remnant lipoprotein component of TGRLs is largely unexplored and the mechanistic basis of their actions poorly defined. This article provides a brief overview of the evidence supporting direct actions of these particles on endothelial cells and highlights the importance of their fatty acid composition and oxidative state as determinants of their cellular actions.