Soluble lectin-like oxidized LDL receptor-1 (sLOX-1) as a sensitive and specific biomarker for acute coronary syndrome—Comparison with other biomarkers

Summary Background Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) appears to be involved in atherosclerotic plaque vulnerability and rupture. Circulating soluble LOX-1 (sLOX-1) levels are dramatically elevated in patients with acute coronary syndrome (ACS), and its diagnostic sensit...

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Bibliographic Details
Published in:Journal of cardiology 2010-09, Vol.56 (2), p.159-165
Main Authors: Kume, Noriaki, MD, PhD, Mitsuoka, Hirokazu, MD, PhD, Hayashida, Kazutaka, MD, PhD, Tanaka, Masaru, MD, PhD, Kominami, Goro, PhD, Kita, Toru, MD, PhD
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - diagnosis
Atherosclerosis
Biomarkers - blood
Cardiovascular
Coronary Angiography
Coronary artery disease
Diagnostic techniques
Fatty Acid Binding Protein 3
Fatty Acid-Binding Proteins - blood
Female
Humans
Male
Middle Aged
Plaque
Scavenger Receptors, Class E - blood
Sensitivity and Specificity
Troponin
Troponin T - blood
Unstable angina
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Summary:Summary Background Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) appears to be involved in atherosclerotic plaque vulnerability and rupture. Circulating soluble LOX-1 (sLOX-1) levels are dramatically elevated in patients with acute coronary syndrome (ACS), and its diagnostic sensitivity and specificity is superior to high-sensitivity C-reactive protein (hs-CRP). In this study, we have compared the diagnostic value of sLOX-1 for ACS with those of troponin T (TnT) and heart-type fatty acid binding protein (H-FABP). Methods One hundred and seven patients who underwent coronary angiography (CAG), including 18 ACS and 89 non-ACS patients were enrolled. Peripheral blood samples were obtained during the emergent or elective CAG. The non-ACS group consisted of 30 patients with normal CAG, 30 stable angina pectoris patients controlled by medical treatment, and 29 patients with stable angina who required elective coronary revascularization (percutaneous coronary intervention or coronary artery bypass graft). Results Age, gender, lipid profiles, or prevalence of diabetes, smoking, or hypertension were not significantly different between ACS and non-ACS. These factors did not significantly affect blood sLOX-1 levels. Circulating sLOX-1, TnT, and H-FABP levels were significantly higher in ACS than non-ACS. Area under the curve (AUC) values of the receiver-operating characteristic curves were 0.948, 0.704, and 0.691 for sLOX-1, TnT, and H-FABP, respectively. In a TnT-negative (
ISSN:0914-5087
1876-4738
DOI:10.1016/j.jjcc.2010.05.002