An Efficient Synthesis of Hydantoins via Sustainable Integration of Coupled Domino Processes

A highly efficient synthesis of hydantoins has been developed from simple and commercially available 1,3-dicarbonyl compounds, ureas, and methyl ketones or terminal aryl alkenes. This protocol involves a sustainable integration of two coupled domino processes: iodine-promoted synthesis of unsymmetri...

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Bibliographic Details
Published in:Organic letters 2010-09, Vol.12 (18), p.4026-4029
Main Authors: Gao, Meng, Yang, Yan, Wu, Yan-Dong, Deng, Cong, Shu, Wen-Ming, Zhang, Dong-Xue, Cao, Li-Ping, She, Neng-Fang, Wu, An-Xin
Format: Article
Language:English
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Summary:A highly efficient synthesis of hydantoins has been developed from simple and commercially available 1,3-dicarbonyl compounds, ureas, and methyl ketones or terminal aryl alkenes. This protocol involves a sustainable integration of two coupled domino processes: iodine-promoted synthesis of unsymmetrical 1,4-enediones (domino I) and the sequential transformation into hydantoins (domino II).
ISSN:1523-7060
1523-7052
DOI:10.1021/ol1015948