Effects of tiapride on homovanillic acid levels in human cerebrospinal fluid drawn at pneumoencephalography

The effect of tiapride on HVA and 5-HIAA levels in the CSF drawn at pneumoencephalography (PEG) was studied. Five consecutive 5 ml fractions of CSF were drawn from control and tiapride-treated subjects. In both groups, a linear increase in HVA concentrations was found between the first and subsequen...

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Bibliographic Details
Published in:Psychopharmacology 1980-01, Vol.71 (1), p.7-9
Main Authors: Spissu, A, Congia, S, Piccardi, M P, Fadda, F, Mangoni, A, Gessa, G L
Format: Article
Language:English
Subjects:
Adult
Benzamides - pharmacology
Homovanillic Acid - cerebrospinal fluid
Humans
Hydroxyindoleacetic Acid - cerebrospinal fluid
Male
Middle Aged
Phenylacetates - cerebrospinal fluid
Pneumoencephalography
Tiapamil Hydrochloride - pharmacology
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Summary:The effect of tiapride on HVA and 5-HIAA levels in the CSF drawn at pneumoencephalography (PEG) was studied. Five consecutive 5 ml fractions of CSF were drawn from control and tiapride-treated subjects. In both groups, a linear increase in HVA concentrations was found between the first and subsequent fractions. On the contrary, no significant difference in 5-HIAA concentrations was found in sequential CSF samples. Tiapride increased the mean HVA concentrations and caused a steeper caudocranial gradient of this metabolite but failed to modify 5-HIAA concentrations. The results suggest that tiapride blocks dopamine (DA) receptors and increases DA synthesis.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00433245