Protection of mice against group B Streptococcus type Ia by IgG components of a rabbit antiserum

IgG fractions were separated by ion exchange chromatography on DEAE-cellulose from hyperimmune rabbit sera prepared against a group B streptococcus type Ia mouse-virulent strain. 50 microgram IgG in conjunction with ampicillin (200 mg/kg) protected mice more effectively against a lethal challenge th...

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Bibliographic Details
Published in:Medical microbiology and immunology 1980, Vol.169 (1), p.9-14
Main Authors: Cleat, P H, Coid, C R
Format: Article
Language:English
Subjects:
Ampicillin - therapeutic use
Animals
Chromatography, DEAE-Cellulose
Female
Immunoglobulin G - administration & dosage
Immunoglobulin G - immunology
Immunoglobulin G - isolation & purification
Mice
Rabbits - immunology
Streptococcal Infections - prevention & control
Streptococcus agalactiae - immunology
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Summary:IgG fractions were separated by ion exchange chromatography on DEAE-cellulose from hyperimmune rabbit sera prepared against a group B streptococcus type Ia mouse-virulent strain. 50 microgram IgG in conjunction with ampicillin (200 mg/kg) protected mice more effectively against a lethal challenge than ampicillin (400 mg/kg) alone or ampicillin (200 mg/kg) combined with gentamicin (10 mg/kg), when administered up to 12 h after infection.
ISSN:0300-8584
DOI:10.1007/BF02123707