Effects of increasing osmolality on rat ileal smooth muscle

The effects of changing bathing medium osmolality on tension generation in smooth muscle were studied on potassium-depolarized segments of rat ileum. Increasing the tonicity of the medium evokes a transient relaxation of the smooth muscle; restoration of isotonicity evokes a transient contraction of...

Full description

Saved in:
Bibliographic Details
Published in:Pflügers Archiv 1980-12, Vol.389 (1), p.75-79
Main Authors: Schiff, J D, Overweg, N I
Format: Article
Language:English
Subjects:
Animals
Calcium - pharmacology
Dose-Response Relationship, Drug
Ileum - physiology
In Vitro Techniques
Muscle Tonus - drug effects
Muscle, Smooth - physiology
Osmolar Concentration
Rats
Sodium - pharmacology
Sodium Chloride - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of changing bathing medium osmolality on tension generation in smooth muscle were studied on potassium-depolarized segments of rat ileum. Increasing the tonicity of the medium evokes a transient relaxation of the smooth muscle; restoration of isotonicity evokes a transient contraction of similar amplitude and time course. While immersed in hypertonic media of less than 1.3 times normal tonicity, the smooth muscle slowly increases its isometric tension; in media of nearly twice normal tonicity, the smooth muscle loses tension. All of these effects occur whether the medium is made hypertonic with added NaCl or sucrose.
ISSN:0031-6768
1432-2013
DOI:10.1007/BF00587931