Anti-malarial activity of ethanolic leaf extract of Piliostigma thonningii Schum. (Caesalpiniacea) in mice infected with Plasmodium berghei berghei

Piliostigma thonningii Schum. (Caesalpiniacea) is used traditionally in the management of fever, cough, wounds and various ulceration. Oral acute toxicity a the ethanolic leaf extract of Piliostigma thorningii was evaluated in mice using modified Lorke's method. The ethanolic leaf extract was e...

Full description

Saved in:
Bibliographic Details
Published in:African journal of biotechnology 2010-06, Vol.9 (23), p.3475-3480
Main Authors: Madara, A A, Ajayi, JA, Salawu, O A, Tijani, A Y
Format: Article
Language:English
Subjects:
Formicidae
Plasmodium berghei
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Piliostigma thonningii Schum. (Caesalpiniacea) is used traditionally in the management of fever, cough, wounds and various ulceration. Oral acute toxicity a the ethanolic leaf extract of Piliostigma thorningii was evaluated in mice using modified Lorke's method. The ethanolic leaf extract was evaluated for in vivo ant plasmodial activity against chloroquine sensitive strain of Plasmodium berghe berghei NK65 in mice. Four day suppressive, curative effect against establishec infection and prophylactic models of anti plasmodial studies were carried out. The oral median lethal dose was determined to be 3807.89 mg/kg body weight. The extract (100,200 and 400 mg/kg) exerted dose dependent chemo suppressive effects at the different levels of the infections tested. However the anti-plasmodia effect of chloroquine at 5 mg/kg body weight was higher than the extract in all the test models. This shows that the plant has anti plasmodial property that can be explored for the management of malaria.
ISSN:1684-5315
1684-5315