Structure, functions, and biosynthesis of glycoconjugates of Leishmania spp. cell surface

Cell surface of leishmaniasis causal agent, a parasitic member of Protozoa of Leishmania genus, is covered by thick glycocalix consisting of various phosphatidylinositol-anchored molecules. This review deals with the structure and biosynthesis of the main phosphoglycans and glycoproteins of Leishman...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2010-06, Vol.75 (6), p.686-694
Main Authors: Novozhilova, N. M., Bovin, N. V.
Format: Article
Language:English
Subjects:
Arabinose - chemistry
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Biosynthesis
Cellular biology
Chemical properties
Glycoconjugates - biosynthesis
Glycoconjugates - chemistry
Glycoconjugates - physiology
Glycolipids - chemistry
Glycolipids - metabolism
Glycoproteins
Glycosphingolipids - biosynthesis
Glycosphingolipids - chemistry
Leishmania
Leishmania - metabolism
Life Sciences
Lipids
Membrane Proteins - biosynthesis
Membrane Proteins - chemistry
Metalloendopeptidases - chemistry
Metalloendopeptidases - metabolism
Microbiology
Molecular structure
Parasites
Physiological aspects
Proteoglycans - biosynthesis
Proteoglycans - chemistry
Protozoan Proteins - biosynthesis
Protozoan Proteins - chemistry
Review
Vector-borne diseases
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Summary:Cell surface of leishmaniasis causal agent, a parasitic member of Protozoa of Leishmania genus, is covered by thick glycocalix consisting of various phosphatidylinositol-anchored molecules. This review deals with the structure and biosynthesis of the main phosphoglycans and glycoproteins of Leishmania cell surface, many of which incorporate the rare natural D-arabinopyranose, and the problem concerning the involvement of these molecules in support of Leishmania survival during their intricate life cycle is discussed.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297910060027