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Differential expression of Notch receptors and their ligands in desmoplastic ameloblastoma
J Oral Pathol Med (2010) 39: 552–558 Background: In mammals, the Notch gene family encodes four receptors (Notch1–4), and all of them are important for cell fate decisions. Notch signaling pathway plays an essential role in tooth development. The ameloblastoma, a benign odontogenic epithelial neopl...
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| Published in: | Journal of oral pathology & medicine 2010-08, Vol.39 (7), p.552-558 |
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| container_issue | 7 |
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| container_title | Journal of oral pathology & medicine |
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| creator | Siar, Chong Huat Nakano, Keisuke Han, Phuu Pwint Nagatsuka, Hitoshi Ng, Kok Han Kawakami, Toshiyuki |
| description | J Oral Pathol Med (2010) 39: 552–558
Background: In mammals, the Notch gene family encodes four receptors (Notch1–4), and all of them are important for cell fate decisions. Notch signaling pathway plays an essential role in tooth development. The ameloblastoma, a benign odontogenic epithelial neoplasm, histologically recapitulates the enamel organ at bell stage. Notch has been detected in the plexiform and follicular ameloblastoma. Its activity in the desmoplastic ameloblastoma is unknown.
Method: Notch1‐4 and their ligands (Jagged1, Jagged2 and Delta1) were examined immunohistochemically in 10 cases of desmoplastic ameloblastoma.
Results: Ameloblastoma tumor epithelium demonstrated positive expression for Notch1 (n = 5/10), Notch3 (n = 8/10), Notch4 (n = 10/10), Jagged1 (n = 6/10) and Delta1 (n = 5/10), but no reactivity for Notch2 (n = 10/10) and Jagged2 (10/10). Expression patterns were distinct with some overlap. Positive activity was detected largely in the cell membrane and cytoplasm of peripheral and central neoplastic epithelial cells, and sometimes in the nucleus. Staining score was highest for Notch4. Stromal components namely endothelial cells and fibroblasts showed overexpression for Notch4 but were mildly or non‐reactive for the other Notch members and their ligands.
Conclusions: These findings suggest that Notch receptors and their ligands may play differing roles during the development of the desmoplastic ameloblastoma with Notch4 probably playing a greater role in the acquisition of tissue‐specific cellular characteristics in the desmoplastic ameloblastoma. |
| doi_str_mv | 10.1111/j.1600-0714.2009.00871.x |
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Background: In mammals, the Notch gene family encodes four receptors (Notch1–4), and all of them are important for cell fate decisions. Notch signaling pathway plays an essential role in tooth development. The ameloblastoma, a benign odontogenic epithelial neoplasm, histologically recapitulates the enamel organ at bell stage. Notch has been detected in the plexiform and follicular ameloblastoma. Its activity in the desmoplastic ameloblastoma is unknown.
Method: Notch1‐4 and their ligands (Jagged1, Jagged2 and Delta1) were examined immunohistochemically in 10 cases of desmoplastic ameloblastoma.
Results: Ameloblastoma tumor epithelium demonstrated positive expression for Notch1 (n = 5/10), Notch3 (n = 8/10), Notch4 (n = 10/10), Jagged1 (n = 6/10) and Delta1 (n = 5/10), but no reactivity for Notch2 (n = 10/10) and Jagged2 (10/10). Expression patterns were distinct with some overlap. Positive activity was detected largely in the cell membrane and cytoplasm of peripheral and central neoplastic epithelial cells, and sometimes in the nucleus. Staining score was highest for Notch4. Stromal components namely endothelial cells and fibroblasts showed overexpression for Notch4 but were mildly or non‐reactive for the other Notch members and their ligands.
Conclusions: These findings suggest that Notch receptors and their ligands may play differing roles during the development of the desmoplastic ameloblastoma with Notch4 probably playing a greater role in the acquisition of tissue‐specific cellular characteristics in the desmoplastic ameloblastoma.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/j.1600-0714.2009.00871.x</identifier><identifier>PMID: 20337864</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Ameloblastoma - pathology ; Biological and medical sciences ; Calcium-Binding Proteins - analysis ; Cell Membrane - ultrastructure ; Cell Nucleus - ultrastructure ; Cytoplasm - ultrastructure ; Dentistry ; desmoplastic ameloblastoma ; Endothelial Cells - pathology ; Epithelial Cells - pathology ; Epithelium - pathology ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Female ; Fibroblasts - pathology ; Gene Expression Regulation, Neoplastic - genetics ; Humans ; Immunohistochemistry ; Intercellular Signaling Peptides and Proteins - analysis ; Intracellular Signaling Peptides and Proteins ; Jagged-1 Protein ; Jagged-2 Protein ; Ligands ; Male ; Mandibular Neoplasms - pathology ; Maxillary Neoplasms - pathology ; Medical sciences ; Membrane Proteins - analysis ; Middle Aged ; Notch ; Otorhinolaryngology. Stomatology ; Proto-Oncogene Proteins - analysis ; Receptor, Notch1 - analysis ; Receptor, Notch2 - analysis ; Receptor, Notch3 ; Receptor, Notch4 ; receptors ; Receptors, Notch - analysis ; Serrate-Jagged Proteins ; Tumors</subject><ispartof>Journal of oral pathology & medicine, 2010-08, Vol.39 (7), p.552-558</ispartof><rights>2010 John Wiley & Sons A/S</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4671-949fddc3626543f3478dd24510c175f19deacadeea9d2646e5fd1f87433dbedb3</citedby><cites>FETCH-LOGICAL-c4671-949fddc3626543f3478dd24510c175f19deacadeea9d2646e5fd1f87433dbedb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23050056$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20337864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siar, Chong Huat</creatorcontrib><creatorcontrib>Nakano, Keisuke</creatorcontrib><creatorcontrib>Han, Phuu Pwint</creatorcontrib><creatorcontrib>Nagatsuka, Hitoshi</creatorcontrib><creatorcontrib>Ng, Kok Han</creatorcontrib><creatorcontrib>Kawakami, Toshiyuki</creatorcontrib><title>Differential expression of Notch receptors and their ligands in desmoplastic ameloblastoma</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>J Oral Pathol Med (2010) 39: 552–558
Background: In mammals, the Notch gene family encodes four receptors (Notch1–4), and all of them are important for cell fate decisions. Notch signaling pathway plays an essential role in tooth development. The ameloblastoma, a benign odontogenic epithelial neoplasm, histologically recapitulates the enamel organ at bell stage. Notch has been detected in the plexiform and follicular ameloblastoma. Its activity in the desmoplastic ameloblastoma is unknown.
Method: Notch1‐4 and their ligands (Jagged1, Jagged2 and Delta1) were examined immunohistochemically in 10 cases of desmoplastic ameloblastoma.
Results: Ameloblastoma tumor epithelium demonstrated positive expression for Notch1 (n = 5/10), Notch3 (n = 8/10), Notch4 (n = 10/10), Jagged1 (n = 6/10) and Delta1 (n = 5/10), but no reactivity for Notch2 (n = 10/10) and Jagged2 (10/10). Expression patterns were distinct with some overlap. Positive activity was detected largely in the cell membrane and cytoplasm of peripheral and central neoplastic epithelial cells, and sometimes in the nucleus. Staining score was highest for Notch4. Stromal components namely endothelial cells and fibroblasts showed overexpression for Notch4 but were mildly or non‐reactive for the other Notch members and their ligands.
Conclusions: These findings suggest that Notch receptors and their ligands may play differing roles during the development of the desmoplastic ameloblastoma with Notch4 probably playing a greater role in the acquisition of tissue‐specific cellular characteristics in the desmoplastic ameloblastoma.</description><subject>Adult</subject><subject>Ameloblastoma - pathology</subject><subject>Biological and medical sciences</subject><subject>Calcium-Binding Proteins - analysis</subject><subject>Cell Membrane - ultrastructure</subject><subject>Cell Nucleus - ultrastructure</subject><subject>Cytoplasm - ultrastructure</subject><subject>Dentistry</subject><subject>desmoplastic ameloblastoma</subject><subject>Endothelial Cells - pathology</subject><subject>Epithelial Cells - pathology</subject><subject>Epithelium - pathology</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Female</subject><subject>Fibroblasts - pathology</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Intercellular Signaling Peptides and Proteins - analysis</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Jagged-1 Protein</subject><subject>Jagged-2 Protein</subject><subject>Ligands</subject><subject>Male</subject><subject>Mandibular Neoplasms - pathology</subject><subject>Maxillary Neoplasms - pathology</subject><subject>Medical sciences</subject><subject>Membrane Proteins - analysis</subject><subject>Middle Aged</subject><subject>Notch</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Proto-Oncogene Proteins - analysis</subject><subject>Receptor, Notch1 - analysis</subject><subject>Receptor, Notch2 - analysis</subject><subject>Receptor, Notch3</subject><subject>Receptor, Notch4</subject><subject>receptors</subject><subject>Receptors, Notch - analysis</subject><subject>Serrate-Jagged Proteins</subject><subject>Tumors</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqNkU9v1DAQxS0EokvhKyBfEKekdvwvkbhAl7ag1ZYDCImL5bXH1EsSp3ZWbL89CbssR_DFHvn3ZkbvIYQpKel0LrYllYQURFFeVoQ0JSG1ouX-EVqcPh6jBWkILypBqzP0LOctIVQxTp-is4owpmrJF-jbMngPCfoxmBbDfkiQc4g9jh6v42jvcAILwxhTxqZ3eLyDkHAbvk9FxqHHDnIXh9bkMVhsOmjjZi5iZ56jJ960GV4c73P05er958ubYnV7_eHy7aqwXCpaNLzxzlkmKyk484yr2rmKC0osVcLTxoGxxgGYxlWSSxDeUV8rzpjbgNuwc_T60HdI8X4HedRdyBba1vQQd1krwQWTkpF_k7xupj2amawPpE0x5wReDyl0Jj1oSvQcgd7q2Wk9O63nCPTvCPR-kr48DtltOnAn4R_PJ-DVETDZmtYn09uQ_3KMCEKEnLg3B-5naOHhvxfQH28_TY9JXhzkIY-wP8lN-qGlYkror-trrVbrK_VuudQ1-wUY9bGS</recordid><startdate>201008</startdate><enddate>201008</enddate><creator>Siar, Chong Huat</creator><creator>Nakano, Keisuke</creator><creator>Han, Phuu Pwint</creator><creator>Nagatsuka, Hitoshi</creator><creator>Ng, Kok Han</creator><creator>Kawakami, Toshiyuki</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>201008</creationdate><title>Differential expression of Notch receptors and their ligands in desmoplastic ameloblastoma</title><author>Siar, Chong Huat ; Nakano, Keisuke ; Han, Phuu Pwint ; Nagatsuka, Hitoshi ; Ng, Kok Han ; Kawakami, Toshiyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4671-949fddc3626543f3478dd24510c175f19deacadeea9d2646e5fd1f87433dbedb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Ameloblastoma - pathology</topic><topic>Biological and medical sciences</topic><topic>Calcium-Binding Proteins - analysis</topic><topic>Cell Membrane - ultrastructure</topic><topic>Cell Nucleus - ultrastructure</topic><topic>Cytoplasm - ultrastructure</topic><topic>Dentistry</topic><topic>desmoplastic ameloblastoma</topic><topic>Endothelial Cells - pathology</topic><topic>Epithelial Cells - pathology</topic><topic>Epithelium - pathology</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Female</topic><topic>Fibroblasts - pathology</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Intercellular Signaling Peptides and Proteins - analysis</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Jagged-1 Protein</topic><topic>Jagged-2 Protein</topic><topic>Ligands</topic><topic>Male</topic><topic>Mandibular Neoplasms - pathology</topic><topic>Maxillary Neoplasms - pathology</topic><topic>Medical sciences</topic><topic>Membrane Proteins - analysis</topic><topic>Middle Aged</topic><topic>Notch</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Proto-Oncogene Proteins - analysis</topic><topic>Receptor, Notch1 - analysis</topic><topic>Receptor, Notch2 - analysis</topic><topic>Receptor, Notch3</topic><topic>Receptor, Notch4</topic><topic>receptors</topic><topic>Receptors, Notch - analysis</topic><topic>Serrate-Jagged Proteins</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siar, Chong Huat</creatorcontrib><creatorcontrib>Nakano, Keisuke</creatorcontrib><creatorcontrib>Han, Phuu Pwint</creatorcontrib><creatorcontrib>Nagatsuka, Hitoshi</creatorcontrib><creatorcontrib>Ng, Kok Han</creatorcontrib><creatorcontrib>Kawakami, Toshiyuki</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siar, Chong Huat</au><au>Nakano, Keisuke</au><au>Han, Phuu Pwint</au><au>Nagatsuka, Hitoshi</au><au>Ng, Kok Han</au><au>Kawakami, Toshiyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential expression of Notch receptors and their ligands in desmoplastic ameloblastoma</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2010-08</date><risdate>2010</risdate><volume>39</volume><issue>7</issue><spage>552</spage><epage>558</epage><pages>552-558</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>J Oral Pathol Med (2010) 39: 552–558
Background: In mammals, the Notch gene family encodes four receptors (Notch1–4), and all of them are important for cell fate decisions. Notch signaling pathway plays an essential role in tooth development. The ameloblastoma, a benign odontogenic epithelial neoplasm, histologically recapitulates the enamel organ at bell stage. Notch has been detected in the plexiform and follicular ameloblastoma. Its activity in the desmoplastic ameloblastoma is unknown.
Method: Notch1‐4 and their ligands (Jagged1, Jagged2 and Delta1) were examined immunohistochemically in 10 cases of desmoplastic ameloblastoma.
Results: Ameloblastoma tumor epithelium demonstrated positive expression for Notch1 (n = 5/10), Notch3 (n = 8/10), Notch4 (n = 10/10), Jagged1 (n = 6/10) and Delta1 (n = 5/10), but no reactivity for Notch2 (n = 10/10) and Jagged2 (10/10). Expression patterns were distinct with some overlap. Positive activity was detected largely in the cell membrane and cytoplasm of peripheral and central neoplastic epithelial cells, and sometimes in the nucleus. Staining score was highest for Notch4. Stromal components namely endothelial cells and fibroblasts showed overexpression for Notch4 but were mildly or non‐reactive for the other Notch members and their ligands.
Conclusions: These findings suggest that Notch receptors and their ligands may play differing roles during the development of the desmoplastic ameloblastoma with Notch4 probably playing a greater role in the acquisition of tissue‐specific cellular characteristics in the desmoplastic ameloblastoma.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20337864</pmid><doi>10.1111/j.1600-0714.2009.00871.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Ameloblastoma - pathology Biological and medical sciences Calcium-Binding Proteins - analysis Cell Membrane - ultrastructure Cell Nucleus - ultrastructure Cytoplasm - ultrastructure Dentistry desmoplastic ameloblastoma Endothelial Cells - pathology Epithelial Cells - pathology Epithelium - pathology Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Fibroblasts - pathology Gene Expression Regulation, Neoplastic - genetics Humans Immunohistochemistry Intercellular Signaling Peptides and Proteins - analysis Intracellular Signaling Peptides and Proteins Jagged-1 Protein Jagged-2 Protein Ligands Male Mandibular Neoplasms - pathology Maxillary Neoplasms - pathology Medical sciences Membrane Proteins - analysis Middle Aged Notch Otorhinolaryngology. Stomatology Proto-Oncogene Proteins - analysis Receptor, Notch1 - analysis Receptor, Notch2 - analysis Receptor, Notch3 Receptor, Notch4 receptors Receptors, Notch - analysis Serrate-Jagged Proteins Tumors |
| title | Differential expression of Notch receptors and their ligands in desmoplastic ameloblastoma |
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