HLA-G polymorphism patterns show lack of detectable association with recurrent spontaneous abortion

• Published in: Tissue antigens 2010-09, Vol.76 (3), p.216-222
• Main Authors: Aruna, M., Sudheer, P. S., Andal, S., Tarakeswari, S., Reddy, A. G., Thangaraj, K., Singh, L., Reddy, B. M.
• Format: Article
• Language: English
• Subjects: Abortion, Habitual - genetics; Abortion, Spontaneous - genetics; Adolescent; Adult; Alleles; association; Case-Control Studies; DNA - analysis; DNA - genetics; Female; Gene Frequency; Histocompatibility Antigens Class I - genetics; HLA Antigens - genetics; HLA-G Antigens; human leukocyte antigen sharing; human leukocyte antigen-G alleles; Humans; Indian population; Male; Polymerase Chain Reaction; Polymorphism, Genetic - genetics; Pregnancy; recurrent spontaneous abortion; Young Adult
• ISSN: 0001-2815; 1399-0039
• DOI: 10.1111/j.1399-0039.2010.01505.x

Human leukocyte antigen‐G (HLA‐G) is a class I non‐classical molecule that is predominantly expressed on the extravillous cytotrophoblasts at foetal–maternal interface during pregnancy. We recruited 143 recurrent spontaneous abortion (RSA) and 150 control couples for the study. DNA‐based typing of the HLA‐G was carried out to explore if we can validate the patterns of association reported elsewhere or find association of novel HLA‐G alleles with RSA in the Indian population. We also evaluated the role of allele sharing in couples with RSA. We did not find association of any of the HLA‐G alleles with RSA in our study. There is a general trend of increase in sharing among the RSA couples, but the increase is not significant. The results suggest that the HLA‐G alleles or the allele sharing by couples may not play a significant role in the manifestation of RSA in the Indian context albeit more studies are required before making any definitive statement.