A review of mortality due to Clostridium difficile infection

Summary In this review we examine published literature to ascertain mortality in relation to Clostridium difficile infection (CDI) and the factors associated with mortality. In the 27 studies that had sufficient data, there were 10975 cases of CDI with great heterogeneity in the methods for reportin...

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Bibliographic Details
Published in:The Journal of infection 2010-07, Vol.61 (1), p.1-8
Main Authors: Karas, J.A, Enoch, D.A, Aliyu, S.H
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Age Factors
Aged
Aged, 80 and over
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Clostridium difficile
Clostridium difficile - isolation & purification
Enterocolitis, Pseudomembranous - mortality
Female
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Hospital acquired infection
Human bacterial diseases
Humans
Infectious Disease
Infectious diseases
Male
Medical sciences
Middle Aged
Mortality
Nosocomial infections
Other diseases. Semiology
Pseudomembranous colitis
Risk Factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Young Adult
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Summary:Summary In this review we examine published literature to ascertain mortality in relation to Clostridium difficile infection (CDI) and the factors associated with mortality. In the 27 studies that had sufficient data, there were 10975 cases of CDI with great heterogeneity in the methods for reporting mortality. We calculated the overall associated mortality to be at least 5.99% within 3 months of diagnosis. The most important finding is that higher mortality is associated with advanced age, being 13.5% in patients over 80 years. Studies performed after 2000 had a significantly higher mortality than those before this date. We propose minimum standards for reporting mortality in future studies.
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2010.03.025