Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits

Electromagnetic-based methods of stimulating brain activity require invasive procedures or have other limitations. Deep-brain stimulation requires surgically implanted electrodes. Transcranial magnetic stimulation does not require surgery, but suffers from low spatial resolution. Optogenetic-based a...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2010-06, Vol.66 (5), p.681-694
Main Authors: Tufail, Yusuf, Matyushov, Alexei, Baldwin, Nathan, Tauchmann, Monica L., Georges, Joseph, Yoshihiro, Anna, Tillery, Stephen I. Helms, Tyler, William J.
Format: Article
Language:English
Subjects:
Animals
Brain
Brain - physiology
Brain research
Hippocampus - physiology
Influence
Methods
Mice
Microscopy
Nerve Net - physiology
Neurons - physiology
Rodents
SYSNEURO
Ultrasonic imaging
Ultrasonics
Ultrasonography, Doppler, Transcranial - methods
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Summary:Electromagnetic-based methods of stimulating brain activity require invasive procedures or have other limitations. Deep-brain stimulation requires surgically implanted electrodes. Transcranial magnetic stimulation does not require surgery, but suffers from low spatial resolution. Optogenetic-based approaches have unrivaled spatial precision, but require genetic manipulation. In search of a potential solution to these limitations, we began investigating the influence of transcranial pulsed ultrasound on neuronal activity in the intact mouse brain. In motor cortex, ultrasound-stimulated neuronal activity was sufficient to evoke motor behaviors. Deeper in subcortical circuits, we used targeted transcranial ultrasound to stimulate neuronal activity and synchronous oscillations in the intact hippocampus. We found that ultrasound triggers TTX-sensitive neuronal activity in the absence of a rise in brain temperature (
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2010.05.008