Electrochemical concentration of no-carrier-added [ super(18)F]fluoride from [ super(18)O]water in a disposable microfluidic cell for radiosynthesis of super(18)F-labeled radiopharmaceuticals

The realization of the electrochemical method for microfluidic radiosynthesis is described for concentrating aqueous no-carrier-added [ super(18)F]fluoride into an aprotic solvent in a disposable microfluidic cell. Flowing aqueous [ super(18)F]fluoride was introduced into a disposable microfluidic c...

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Bibliographic Details
Published in:Applied radiation and isotopes 2010-09, Vol.68 (9), p.1703-1708
Main Authors: Saiki, Hidekazu, Iwata, Ren, Nakanishi, Hiroaki, Wong, Rebecca, Ishikawa, Yoichi, Furumoto, Shozo, Yamahara, Ryo, Sakamoto, Katsumasa, Ozeki, Eiichi
Format: Article
Language:English
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Summary:The realization of the electrochemical method for microfluidic radiosynthesis is described for concentrating aqueous no-carrier-added [ super(18)F]fluoride into an aprotic solvent in a disposable microfluidic cell. Flowing aqueous [ super(18)F]fluoride was introduced into a disposable microfluidic cell (16 kL) under an electric potential (10 V), followed by anhydrous MeCN. The trapped [ super(18)F]fluoride was released in MeCN containing Kryptofix 222-KHCO sub(3) (ca. 60 kL) under heat and a reversed potential (-2.5 V). An automated module provided the [ super(18)F]fluoride ready for subsequent microfluidic radiosynthesis in overall radiochemical yields of 60% within 6 min.
ISSN:0969-8043
DOI:10.1016/j.apradiso.2010.02.005