Nonlinear temporal organization of neuronal discharge in the basal ganglia of Parkinson's disease patients

Previous electrophysiological studies of the basal ganglia in Parkinson's disease (PD) patients have utilized linear analyses in time-or-frequency domains to characterize neuronal discharge patterns. However, these measures do not fully describe the non-linear features of discharge rates and os...

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Bibliographic Details
Published in:Experimental neurology 2010-08, Vol.224 (2), p.542-544
Main Authors: Lim, Jongil, Sanghera, Manjit K., Darbin, Olivier, Stewart, R. Malcolm, Jankovic, Joseph, Simpson, Richard
Format: Article
Language:English
Subjects:
Action Potentials
Basal Ganglia - physiopathology
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Globus Pallidus
Globus Pallidus - physiopathology
Humans
Information Theory
Inter-spike interval
Linear Models
Medical sciences
Neurology
Neurons - physiology
Non-linear analyses
Parkinson Disease - physiopathology
Subthalamic nucleus
Subthalamic Nucleus - physiopathology
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Summary:Previous electrophysiological studies of the basal ganglia in Parkinson's disease (PD) patients have utilized linear analyses in time-or-frequency domains to characterize neuronal discharge patterns. However, these measures do not fully describe the non-linear features of discharge rates and oscillatory activities of basal ganglia neurons. In this original research, we investigate whether non-linear temporal organizations exist in the inter-spike interval series of neurons recorded in the globus pallidus or the subthalamic nucleus in PD patients undergoing surgery for the implantation of deep brain stimulating electrodes. Our data indicate that in approximately 80% of globus pallidus and subthalamic neurons, the raw inter-spike interval sequences have lower entropy values than those observed after shuffling of the original series. This is the first report establishing non-linear temporal organization as a common feature of neuronal discharge in the basal ganglia of PD patients.
ISSN:0014-4886
1090-2430
DOI:10.1016/j.expneurol.2010.05.021