MicroRNA Gene Regulatory Pathways in the Establishment and Maintenance of ESC Identity

Understanding the molecular foundations of embryonic stem cell (ESC) self-renewal and pluripotency will facilitate therapeutic exploitation of these remarkable cells. Here we discuss the emerging roles of microRNAs in the establishment and maintenance of ESC identity and summarize our current unders...

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Bibliographic Details
Published in:Cell stem cell 2010-07, Vol.7 (1), p.31-35
Main Authors: Martinez, Natalia J., Gregory, Richard I.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Cycle - genetics
Cell Cycle - physiology
Cell Differentiation - genetics
Cell Differentiation - physiology
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Embryonic Stem Cells - cytology
Embryonic Stem Cells - metabolism
Fundamental and applied biological sciences. Psychology
MicroRNAs - genetics
MicroRNAs - physiology
Models, Biological
Molecular and cellular biology
Signal Transduction - genetics
Signal Transduction - physiology
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Summary:Understanding the molecular foundations of embryonic stem cell (ESC) self-renewal and pluripotency will facilitate therapeutic exploitation of these remarkable cells. Here we discuss the emerging roles of microRNAs in the establishment and maintenance of ESC identity and summarize our current understanding of the mechanisms controlling microRNA expression and function in ESCs.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2010.06.011