Molecular Aspects of the Transport and Toxicity of Ochratoxin A

Ochratoxins are a class of naturally occurring compounds produced by several fungi. The most toxic is ochratoxin A (OTA), and occurrence of some human nephropathies and tumors correlate with enhanced OTA exposure. In this Account, the following areas are examined:  molecular details of the binding o...

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Bibliographic Details
Published in:Accounts of chemical research 2004-11, Vol.37 (11), p.874-881
Main Authors: Dai, Jian, Park, Gyungse, Perry, Jennifer L, Il'ichev, Yuri V, Bow, Daniel A. J, Pritchard, John B, Faucet, Virginie, Pfohl-Leszkowicz, Annie, Manderville, Richard A, Simon, John D
Format: Article
Language:English
Subjects:
Albumins - metabolism
Autoradiography
Biological Transport
Humans
Ochratoxins - metabolism
Ochratoxins - toxicity
Oxidation-Reduction
Protein Binding
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Summary:Ochratoxins are a class of naturally occurring compounds produced by several fungi. The most toxic is ochratoxin A (OTA), and occurrence of some human nephropathies and tumors correlate with enhanced OTA exposure. In this Account, the following areas are examined:  molecular details of the binding of OTA to human ser-um albumin (HSA), the influences of binding to HSA on the trans-port of OTA across epithelial cell membranes by organic anion transport proteins, the oxidative activation of OTA, and the for-mation of OTA adducts with biological molecules. These studies are beginning to provide a detailed chemical model for the trans-port, accumulation, and genotoxic and carcinogenic effects of OTA.
ISSN:0001-4842
1520-4898
DOI:10.1021/ar0302134