Proline-Containing Cyclopeptides from the Marine Sponge Phakellia fusca

Four new cyclopeptides, phakellistatins 15−18 (2−5), together with five known cyclopeptides, phakellistatin 13 (1), hymenistatin 1, and hymenamides G, H, and J, were isolated from the South China Sea sponge Phakellia fusca. Their structures were elucidated by HR-ESIMS, NMR, and MALDI-TOF/TOF sequenc...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2010-04, Vol.73 (4), p.650-655
Main Authors: Zhang, Hong-Jun, Yi, Yang-Hua, Yang, Gen-Jin, Hu, Min-Ye, Cao, Gui-Dong, Yang, Fan, Lin, Hou-Wen
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
General pharmacology
Marine
Marine Biology
Medical sciences
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Phakellia
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera - chemistry
Proline - chemistry
Stereoisomerism
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Summary:Four new cyclopeptides, phakellistatins 15−18 (2−5), together with five known cyclopeptides, phakellistatin 13 (1), hymenistatin 1, and hymenamides G, H, and J, were isolated from the South China Sea sponge Phakellia fusca. Their structures were elucidated by HR-ESIMS, NMR, and MALDI-TOF/TOF sequence analysis. The absolute configurations of the amino acid residues of 2−5 were assigned to be l by enantioselective HPLC analysis.
ISSN:0163-3864
1520-6025
DOI:10.1021/np9008267