Cowpea Mosaic Virus for Material Fabrication:  Addressable Carboxylate Groups on a Programmable Nanoscaffold

For the first time, decoration of surface-exposed carboxylate groups on Cowpea mosaic virus particles is reported, thus increasing the number and types of addressable surface groups on this nanoscaffold. First, the addressabilty of carboxylates was demonstrated using a carboxylate-selective fluoresc...

Full description

Saved in:
Bibliographic Details
Published in:Langmuir 2006-04, Vol.22 (8), p.3488-3490
Main Authors: Steinmetz, Nicole F, Lomonossoff, George P, Evans, David J
Format: Article
Language:English
Subjects:
Biomedical Engineering
Biosensing Techniques
Carboxylic Acids - chemistry
Catalysis
Chemistry
Comovirus - metabolism
Cowpea mosaic virus
Electronics
Electrons
Ethidium - chemistry
Exact sciences and technology
Fluorescent Dyes - pharmacology
General and physical chemistry
Models, Chemical
Nanoparticles - chemistry
Nanotechnology - methods
Oxidation-Reduction
Solvents - chemistry
Surface Properties
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:For the first time, decoration of surface-exposed carboxylate groups on Cowpea mosaic virus particles is reported, thus increasing the number and types of addressable surface groups on this nanoscaffold. First, the addressabilty of carboxylates was demonstrated using a carboxylate-selective fluorescent dye, N-cyclohexyl-N‘-(4-(dimethylamino)naphthyl)carbodiimide. Second, it was shown that the virions can be decorated with approximately 180 redox active, methyl(aminopropyl)viologen moieties by coupling to the surface carboxylates. The display of multiple redox centers on the virus particle surface may lead to the development of novel electron-transfer mediators in redox catalysis, to biosensors, and to nanoelectronic devices such as molecular batteries.
ISSN:0743-7463
1520-5827
DOI:10.1021/la060078e