Microbial Transformation of Benzosampangine

Microbial transformation studies of the synthetic antifungal alkaloid benzosampangine (1) have revealed that 1 is metabolized by a number of microorganisms. Using a standard two-stage fermentation technique Absidia glauca (ATCC 22752), Cunninghamella blakesleeana (ATCC 8688a), Cunninghamella species...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2000-03, Vol.63 (3), p.396-398
Main Authors: Orabi, Khaled Y, Clark, Alice M, Hufford, Charles D
Format: Article
Language:English
Subjects:
Absidia
absidia glauca
alkaloids
Alkaloids - chemistry
Alkaloids - pharmacokinetics
Annonaceae
bark
beta-glucopyranose
Bioconversions. Hemisynthesis
biodegradation
Biological and medical sciences
Biotechnology
chemical constituents of plants
chemical structure
cleistopholis patens
Cunninghamella
Cunninghamella blakesleeana
Fundamental and applied biological sciences. Psychology
Fungi - metabolism
Fusarium solani
Fusarium solani f. sp. cucurbitae
Heterocyclic Compounds, 4 or More Rings
metabolites
Methods. Procedures. Technologies
Molecular Structure
Quinolines
Rhizopogon
roots
spectral analysis
Spectrum Analysis
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Summary:Microbial transformation studies of the synthetic antifungal alkaloid benzosampangine (1) have revealed that 1 is metabolized by a number of microorganisms. Using a standard two-stage fermentation technique Absidia glauca (ATCC 22752), Cunninghamella blakesleeana (ATCC 8688a), Cunninghamella species (NRRL 5695), Fusarium solani f. sp. cucurbitae (CSIH #C-5), and Rhizopogon species (ATCC 36060) each produced a β-glucopyranose conjugate of benzosampangine (2). The identity of 2 was established on the basis of spectroscopic data.
ISSN:0163-3864
1520-6025
DOI:10.1021/np990493p