Preparation of Protein−Silicate Hybrids from Polyamine Intercalation of Layered Montmorillonite

Hybrids of the model BSA protein and layered silicate clay with d spacing of ∼62 Å were prepared from either direct or stepwise intercalation. The pristine montmorilloinite (Na+-MMT) was first modified by poly(oxyalkylene)-amine salts (POP- and POE-amine) of 2000 g/mol M w to a gallery-expanded sili...

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Bibliographic Details
Published in:Langmuir 2007-02, Vol.23 (4), p.1995-1999
Main Authors: Lin, Jiang-Jen, Wei, Jiun-Chiou, Juang, Tzong-Yuan, Tsai, Wei-Cheng
Format: Article
Language:English
Subjects:
Adsorption
Amines - chemistry
Animals
Bentonite - chemistry
Cattle
Chemistry
Electrochemistry
Exact sciences and technology
General and physical chemistry
Hydrogen-Ion Concentration
Hydrophobic and Hydrophilic Interactions
Microscopy, Atomic Force
Microscopy, Electron, Transmission
Polyamines - chemistry
Serum Albumin, Bovine - chemistry
Silicates - chemistry
Temperature
X-Ray Diffraction
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Summary:Hybrids of the model BSA protein and layered silicate clay with d spacing of ∼62 Å were prepared from either direct or stepwise intercalation. The pristine montmorilloinite (Na+-MMT) was first modified by poly(oxyalkylene)-amine salts (POP- and POE-amine) of 2000 g/mol M w to a gallery-expanded silicate (d spacing = 53 and 18 Å, respectively), which became accessible for BSA protein embedding. Subsequent BSA substitution allowed the embedding of the protein into the layered clay galleries in an uncompressed conformation. The stepwise process of embedding large molecules into the silicate gallery provides a new method for synthesizing biomaterial/clay hybrids potentially useful in drug delivery or biomedical design.
ISSN:0743-7463
1520-5827
DOI:10.1021/la062013h