Polyhydroxysteroidal Glycosides from the Starfish Anthenea chinensis

• Published in: Journal of natural products (Washington, D.C.) D.C.), 2010-04, Vol.73 (4), p.590-597
• Main Authors: Ma, Ning, Tang, Hai-Feng, Qiu, Feng, Lin, Hou-Wen, Tian, Xiang-Rong, Yao, Min-Na
• Format: Article
• Language: English
• Subjects: Animals; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Asteroidea; Biological and medical sciences; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; General pharmacology; Glycosides - chemistry; Glycosides - isolation & purification; Glycosides - pharmacology; Humans; K562 Cells; Marine; Medical sciences; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Starfish - chemistry; Steroids - chemistry; Steroids - isolation & purification; Steroids - pharmacology; Tubulin Modulators - chemistry; Tubulin Modulators - isolation & purification; Tubulin Modulators - pharmacology
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np9007188

Ten new polyhydroxysteroidal glycosides, anthenosides B−K (2−11), were isolated from the ethanol extract of the starfish Anthenea chinensis. Their structures were elucidated by extensive spectroscopic studies and chemical evidence. The unprecedented carbohydrate chain 6-O-methyl-β-d-galactofuranosyl-(1→3)-(6-O-methyl-β-d-galactofuranose) was present in all the compounds except compounds 10 and 11. Compounds 5, 7, a mixture of 8 and 9, and a mixture of 10 and 11 showed inhibitory activity against human tumor K-562 and BEL-7402 cells. Furthermore, the mixture of 10 and 11 also exhibited cytotoxicity against human tumor U87MG cells and promoted tubulin polymerization.