Recognition of Risk for Clinically Significant Drug Interactions among HIV-Infected Patients Receiving Antiretroviral Therapy

We assessed the risk of clinically significant drug interactions in patients receiving antiretrovirals, and their recognition by physicians. Clinically significant drug interactions were recorded in 27% of 159 patients, with 15% of interactions potentially lowering antiretroviral concentrations. Ris...

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Bibliographic Details
Published in:Clinical infectious diseases 2010-05, Vol.50 (10), p.1419-1421
Main Authors: Evans-Jones, John G., Cottle, Lucy E., Back, David J., Gibbons, Sara, Beeching, Nicholas J., Carey, Peter B., Khoo, Saye H.
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-HIV Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral drugs
Antiretroviral Therapy, Highly Active
Antiretrovirals
Antiviral agents
Antivirals
Biological and medical sciences
Clinical medicine
Dosage
Drug Interactions
Drug therapy
Ethnicity
Female
Health Services Research
HIV
HIV Infections - drug therapy
HIV/AIDS
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Male
Medical sciences
Medications
Middle Aged
Patients
Pharmacology. Drug treatments
Physicians
Prescription drugs
Proteases
Risk Assessment
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral load
Young Adult
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Summary:We assessed the risk of clinically significant drug interactions in patients receiving antiretrovirals, and their recognition by physicians. Clinically significant drug interactions were recorded in 27% of 159 patients, with 15% of interactions potentially lowering antiretroviral concentrations. Risk of clinically significant drug interactions was significantly related to receipt of protease inhibitors. Only 36% of clinically significant drug interactions were correctly identified by physicians.
ISSN:1058-4838
1537-6591
DOI:10.1086/652149