Antileishmaniasis Activity of Flavonoids from Consolida oliveriana

A set of flavonoids from Consolida oliveriana, kaempferol (1), quercetin (2), trifolin (3), and acetyl hyperoside (5) and their O-acetyl derivatives (1a, 2a, 3a), and octa-O-acetylhyperoside (4) showed leishmanicidal activity against promastigote as well as amastigote forms of Leishmania spp. The ce...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2009-06, Vol.72 (6), p.1069-1074
Main Authors: Marín, Clotilde, Boutaleb-Charki, Samira, Díaz, Jesús G, Huertas, Oscar, Rosales, María J, Pérez-Cordon, Gregorio, Guitierrez-Sánchez, Ramon, Sánchez-Moreno, Manuel
Format: Article
Language:English
Subjects:
Animals
antimicrobial properties
Antimony Sodium Gluconate - pharmacology
antiprotozoal agents
Antiprotozoal Agents - chemistry
Antiprotozoal Agents - isolation & purification
Antiprotozoal Agents - therapeutic use
Biological and medical sciences
cell proliferation
chemical concentration
Consolida
Consolida oliveriana
cytotoxicity
dosage
dose response
Female
flavonoids
Flavonoids - chemistry
Flavonoids - isolation & purification
Flavonoids - therapeutic use
Galactosides - pharmacology
General pharmacology
Kaempferols - pharmacology
Leishmania
Leishmania - drug effects
Leishmania braziliensis
Leishmania peruviana
leishmaniasis
Leishmaniasis - drug therapy
Medical sciences
medicinal plants
medicinal properties
Meglumine - pharmacology
Molecular Structure
Organometallic Compounds - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Ranunculaceae - chemistry
Rats
Rats, Inbred Strains
Turkey
ultrastructure
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Summary:A set of flavonoids from Consolida oliveriana, kaempferol (1), quercetin (2), trifolin (3), and acetyl hyperoside (5) and their O-acetyl derivatives (1a, 2a, 3a), and octa-O-acetylhyperoside (4) showed leishmanicidal activity against promastigote as well as amastigote forms of Leishmania spp. The cellular proliferation, metabolic, and ultrastructural studies showed that the acetylated compounds 2a, 3a, and 4 were highly active against Leishmania (V.) peruviana, while 2a as well as 4 were effective against Leishmania (V.) braziliensis. These compounds were not cytotoxic and are effective at similar concentrations up to or lower than the reference drugs (pentostam and glucantim).
ISSN:0163-3864
1520-6025
DOI:10.1021/np8008122