In Vitro Studies on the Effect of Physical Cross-Linking on the Biological Performance of Aliphatic Poly(urethane urea) for Blood Contact Applications

The effect of physical cross-linking in candidate cycloaliphatic and hydrophobic poly(urethane urea) (4,4‘-methylenebis(cyclohexylisocyanate), H12MDI/hydroxy-terminated polybutadiene, HTPBD/hexamethylenediamine, HDA) and poly(ether urethane urea)s (H12MDI/HTPBD-PTMG/HDA) on the in vitro calcificatio...

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Bibliographic Details
Published in:Biomacromolecules 2001, Vol.2 (2), p.588-596
Main Authors: Thomas, Vinoy, Kumari, T. V, Jayabalan, Muthu
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials
Blood Platelets - cytology
Cell Count
Cell Survival - drug effects
Cells, Cultured
Cross-Linking Reagents - chemistry
Erythrocytes - cytology
Humans
In Vitro Techniques
Leukocytes - cytology
Lipids - chemistry
Polyesters - chemistry
Polyesters - metabolism
Polyesters - toxicity
Polyurethanes - chemistry
Polyurethanes - metabolism
Polyurethanes - toxicity
Rabbits
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Summary:The effect of physical cross-linking in candidate cycloaliphatic and hydrophobic poly(urethane urea) (4,4‘-methylenebis(cyclohexylisocyanate), H12MDI/hydroxy-terminated polybutadiene, HTPBD/hexamethylenediamine, HDA) and poly(ether urethane urea)s (H12MDI/HTPBD-PTMG/HDA) on the in vitro calcification and blood−material interaction was studied. All the candidate poly(urethane urea)s and poly(ether urethane urea)s elicit acceptable hemolytic activity, cytocompatibility, calcification, and blood compatibility in vitro. The studies on blood−material interaction reveal that the present poly(urethane urea)s are superior to polystyrene microtiter plates which were used for the studies on blood−material interaction. The present investigation reveals the influence of physical cross-link density on biological interaction differently with poly(urethane urea) and poly(ether urethane urea)s. The higher the physical cross-link density in the poly(urethane urea)s, the higher the calcification and consumption of WBC in whole blood. On the other hand, the higher the physical cross-link density in the poly(ether urethane urea)s, the lesser the calcification and consumption of WBC in whole blood. However a reverse of the above trend has been observed with the platelet consumption in the poly(urethane urea)s and poly(ether urethane urea)s.
ISSN:1525-7797
1526-4602
DOI:10.1021/bm010044f