Fully Convergent Solid Phase Synthesis of Antifreeze Glycoprotein Analogues

The convergent solid phase synthesis of C-linked analogues of antifreeze glycoprotein (AFGP) has been achieved. In this approach, three to six carbohydrate residues are simultaneously coupled to a resin-bound polypeptide. Glycopeptides ranging from 1.6 to 3.0 kDa are easily prepared in 26−44% yield...

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Bibliographic Details
Published in:Biomacromolecules 2001, Vol.2 (2), p.557-561
Main Authors: Eniade, Adewale, Ben, Robert N
Format: Article
Language:English
Subjects:
Antifreeze Proteins - chemical synthesis
Disaccharides - chemistry
Glycosylation
Molecular Weight
Resins, Synthetic - chemistry
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Summary:The convergent solid phase synthesis of C-linked analogues of antifreeze glycoprotein (AFGP) has been achieved. In this approach, three to six carbohydrate residues are simultaneously coupled to a resin-bound polypeptide. Glycopeptides ranging from 1.6 to 3.0 kDa are easily prepared in 26−44% yield demonstrating the utility of this approach.
ISSN:1525-7797
1526-4602
DOI:10.1021/bm0155120