Relationships between inflammatory bowel disease and perinatal factors: Both maternal and paternal disease are related to preterm birth of offspring

• Published in: Inflammatory bowel diseases 2010-05, Vol.16 (5), p.847-855
• Main Authors: Bengtson, May‐Bente, Solberg, Inger Camilla, Aamodt, Geir, Jahnsen, Jørgen, Moum, Bjørn, Vatn, Morten H.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Birth Weight; Case-Control Studies; Cesarean Section; Child; Child, Preschool; Cohort Studies; Colitis, Ulcerative - complications; Colitis, Ulcerative - epidemiology; Crohn Disease - complications; Crohn Disease - epidemiology; familial IBD; Fathers; Female; Follow-Up Studies; Humans; Incidence; Infant, Newborn; inflammatory bowel disease; Male; maternal IBD; paternal IBD; perinatal factors; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Premature Birth - epidemiology; Premature Birth - etiology; Prospective Studies; Risk Factors; Young Adult
• ISSN: 1078-0998; 1536-4844
• DOI: 10.1002/ibd.21120

Background: The aims of this study were to explore the influences of familial, maternal, and paternal inflammatory disease (IBD) on perinatal outcomes in the offspring and the risk for development of IBD related to perinatal factors. Methods: Eighty‐five patients with Crohn's disease (CD) and 86 with ulcerative colitis (UC) were included from a population‐based incidence study enrolled 1990–1994. Family and birth records of these patients, as well as of their 207 infants, were drawn from the Norwegian Medical Birth Registry, established in 1967, and compared with the national birth cohort from the same period. Results: Maternal (odds ratio [OR] = 2.15, 95% confidence interval [CI]: 1.36, 3.39) and paternal IBD (OR = 3.02, 95% CI: 1.82, 5.01) influenced the risk of preterm birth (