Rapid Sequencing of Individual DNA Molecules in Graphene Nanogaps

I propose a technique for reading the base sequence of a single DNA molecule using a graphene nanogap to read the DNA’s transverse conductance. Because graphene is a single atom thick, single-base resolution of the conductance is readily obtained. The nonlinear current−voltage characteristic is used...

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Bibliographic Details
Published in:Nano letters 2010-02, Vol.10 (2), p.420-425
Main Author: Postma, Henk W. Ch
Format: Article
Language:English
Subjects:
Bacterial Toxins - chemistry
Bacterial Toxins - genetics
Carbon - chemistry
Cross-disciplinary physics: materials science
rheology
DNA - chemistry
DNA, Single-Stranded - genetics
Electrophysiology - methods
Exact sciences and technology
Fullerenes and related materials
diamonds, graphite
Hemolysin Proteins - chemistry
Hemolysin Proteins - genetics
Materials science
Models, Statistical
Nanotechnology - methods
Physics
Sequence Analysis, DNA - methods
Silicon Dioxide - chemistry
Specific materials
Stochastic Processes
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Summary:I propose a technique for reading the base sequence of a single DNA molecule using a graphene nanogap to read the DNA’s transverse conductance. Because graphene is a single atom thick, single-base resolution of the conductance is readily obtained. The nonlinear current−voltage characteristic is used to determine the base type independent of nanogap-width variations that cause the current to change by 5 orders of magnitude. The expected sequencing error rate is 0% up to a nanogap width of 1.6 nm.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl9029237