Multiple Aspergillus brain abscesses in immuno-competent patient with severe cranio-facial trauma

Aspergillosis of the central nervous system (CNS) is a rare, but well described disease in immuno-competent patients. We present a 65-year-old patient who developed neuro-aspergillosis 10 months after severe cranio-facial trauma (Le Fort III). He was treated successfully with surgery including stere...

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Bibliographic Details
Published in:Acta neurochirurgica 2007-06, Vol.149 (6), p.629-632
Main Authors: Marinovic, T, Skrlin, J, Vilendecic, M, Rotim, K, Grahovac, G
Format: Article
Language:English
Subjects:
Aged
Amphotericin B - administration & dosage
Antifungal Agents - administration & dosage
Aspergillus
Brain Abscess - diagnosis
Brain Abscess - drug therapy
Brain Abscess - immunology
Brain Abscess - surgery
Cerebral Ventricles - surgery
Cerebrospinal Fluid Shunts
Combined Modality Therapy
Drug Administration Schedule
Facial Injuries - surgery
Humans
Hydrocephalus - surgery
Immunocompetence - immunology
Itraconazole - administration & dosage
Male
Maxillary Fractures - surgery
Meningitis, Fungal - diagnosis
Meningitis, Fungal - drug therapy
Meningitis, Fungal - immunology
Meningitis, Fungal - surgery
Microsurgery
Motor Cortex - surgery
Nervous system
Neuroaspergillosis - diagnosis
Neuroaspergillosis - drug therapy
Neuroaspergillosis - immunology
Neuroaspergillosis - surgery
Neuronavigation
Osteotomy, Le Fort
Postoperative Complications - diagnosis
Postoperative Complications - drug therapy
Postoperative Complications - immunology
Postoperative Complications - surgery
Reoperation
Skull Fractures - surgery
Tomography, X-Ray Computed
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Summary:Aspergillosis of the central nervous system (CNS) is a rare, but well described disease in immuno-competent patients. We present a 65-year-old patient who developed neuro-aspergillosis 10 months after severe cranio-facial trauma (Le Fort III). He was treated successfully with surgery including stereotactic drainage and, with Amphotericin B, Liposomal Amphotericin B, and Itraconazol.
ISSN:0001-6268
0942-0940
DOI:10.1007/s00701-007-1148-7