Pediatric primary CNS lymphoma: longterm survival after treatment with radiation monotherapy

Primary central nervous system lymphoma (PCNSL) in childhood is very rare. We report a 5-year-old boy who presented with headache and nausea. Magnetic resonance imaging (MRI) showed a faintly enhanced lesion in the left cerebellar hemisphere. MRI-guided biopsy was returned with a histopathological d...

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Bibliographic Details
Published in:Acta neurochirurgica 2007-03, Vol.149 (3), p.295-298
Main Authors: Makino, K, Nakamura, H, Yano, S, Kuratsu, J-I
Format: Article
Language:English
Subjects:
Biopsy
Cerebellar Neoplasms - pathology
Cerebellar Neoplasms - radiotherapy
Cerebellum - pathology
Child, Preschool
Cranial Irradiation
Follow-Up Studies
Humans
Lymphoma - diagnosis
Lymphoma - pathology
Lymphoma - radiotherapy
Magnetic Resonance Imaging
Male
Nervous system
Radiation therapy
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Description
Summary:Primary central nervous system lymphoma (PCNSL) in childhood is very rare. We report a 5-year-old boy who presented with headache and nausea. Magnetic resonance imaging (MRI) showed a faintly enhanced lesion in the left cerebellar hemisphere. MRI-guided biopsy was returned with a histopathological diagnosis of lymphoma. Cranial radiotherapy alone with whole-brain irradiation (30 Gy) followed by a 20-Gy booster to the tumor bed was successful and the patient is alive, well, and in persistent complete remission 14 years post-treatment. This is the only pediatric PCNSL encountered at our institution between 1989 and 2004.
ISSN:0001-6268
0942-0940
DOI:10.1007/s00701-006-1094-9