Anti-glycative and anti-inflammatory effects of caffeic acid and ellagic acid in kidney of diabetic mice

Protective effects of caffeic acid (CA) and ellagic acid (EA) in kidney of diabetic mice were examined. CA or EA at 2.5 and 5% was mixed in diet and supplied to diabetic mice for 12 wk. Results showed that the intake of CA or EA increased renal content of these compounds, alleviated body weight loss...

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Bibliographic Details
Published in:Molecular nutrition & food research 2010-03, Vol.54 (3), p.388-395
Main Authors: Chao, Che-yi, Mong, Mei-chin, Chan, Kung-chi, Yin, Mei-chin
Format: Article
Language:English
Subjects:
Aldehyde Reductase - genetics
Aldehyde Reductase - metabolism
Aldose reductase
Animals
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Biological and medical sciences
Biomarkers - blood
Biomarkers - metabolism
Caffeic Acids - administration & dosage
Caffeic Acids - metabolism
Caffeic Acids - therapeutic use
Cytokines - genetics
Cytokines - metabolism
Diabetes
Diabetes Mellitus, Experimental - complications
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - physiopathology
Diabetic Nephropathies - drug therapy
Diabetic Nephropathies - metabolism
Diabetic Nephropathies - physiopathology
Diabetic Nephropathies - prevention & control
Ellagic Acid - administration & dosage
Ellagic Acid - metabolism
Ellagic Acid - therapeutic use
Food industries
Fructose - metabolism
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - drug effects
Glycation
Glycation End Products, Advanced - metabolism
Glycosylation - drug effects
Kidney - drug effects
Kidney - metabolism
Kidney - physiopathology
Kidney Function Tests
L-Iditol 2-Dehydrogenase - metabolism
Male
Mice
Mice, Inbred BALB C
Monocyte chemoattractant protein-1
RNA, Messenger - metabolism
Sorbitol - metabolism
Time Factors
Tumor necrosis factor-α
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Summary:Protective effects of caffeic acid (CA) and ellagic acid (EA) in kidney of diabetic mice were examined. CA or EA at 2.5 and 5% was mixed in diet and supplied to diabetic mice for 12 wk. Results showed that the intake of CA or EA increased renal content of these compounds, alleviated body weight loss, decreased urine output, increased plasma insulin and decreased blood glucose levels at weeks 6 and 12 (p
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.200900087