Thyroid dysfunction in a UK hepatitis C population treated with interferon-[alpha] and ribavirin combination therapy

Summary Objective To assess the incidence of thyroid dysfunction (TD) in a UK cohort of patients with hepatitis C virus (HCV) infection treated with interferon-[alpha] (IFN[alpha]) and ribavirin combination therapy (IFN/RBV). Design, patients and measurements A retrospective study of 288 patients wh...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2010-08, Vol.73 (2), p.249-256
Main Authors: Costelloe, Seán J, Wassef, Nancy, Schulz, Josephine, Vaghijiani, Tina, Morris, Catherine, Whiting, Stephen, Thomas, Michael, Dusheiko, Geoffrey, Jacobs, Michael, Vanderpump, Mark P J
Format: Article
Language:English
Subjects:
a-Interferon
Antibodies
Data processing
Graves' disease
Hepatitis
Hepatitis C
Hepatitis C virus
Hormones
Hypothyroidism
Infection
Iodide peroxidase
Isotopes
medical records
Older people
Ribavirin
Risk assessment
Thyroid
Thyroid-stimulating hormone
Thyroiditis
Thyroxine
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Summary:Summary Objective To assess the incidence of thyroid dysfunction (TD) in a UK cohort of patients with hepatitis C virus (HCV) infection treated with interferon-[alpha] (IFN[alpha]) and ribavirin combination therapy (IFN/RBV). Design, patients and measurements A retrospective study of 288 patients who received IFN/RBV for HCV during a 2-year period from January 2006 was performed. Thyroid function was assessed during a 24-week or 48-week course of IFN/RBV. If serum thyrotrophin (TSH) became undetectable (
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2010.03785.x