Immunostimulation to reduce recurrence after surgery for anal condyloma acuminata: a prospective randomized controlled trial

Aim  Human papillomavirus is the most common cause of sexually transmitted disease. It is associated with immunosuppression and shows a marked tendency to recur. We investigated a natural immunostimulant aimed to reduce recurrence. Method  A randomized controlled study was carried out including 261...

Full description

Saved in:
Bibliographic Details
Published in:Colorectal disease 2010-08, Vol.12 (8), p.799-803
Main Authors: Mistrangelo, M., Cornaglia, S., Pizzio, M., Rimonda, R., Gavello, G., Dal Conte, I., Mussa, A.
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - therapeutic use
Adolescent
Adult
Andrographis
Anogenital warts
Anus Diseases - surgery
Anus Diseases - therapy
Anus Diseases - virology
Carica
Child
Citrus paradisi
condylomata acuminata
Condylomata Acuminata - surgery
Condylomata Acuminata - therapy
current therapies
Echinacea
Female
Human immunodeficiency virus
Human papillomavirus
Humans
immunomodulation
Male
Middle Aged
natural therapies
Phytotherapy - methods
Plant Preparations - therapeutic use
Prospective Studies
recurrences
Secondary Prevention
Statistics, Nonparametric
Tabebuia
Uncaria
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim  Human papillomavirus is the most common cause of sexually transmitted disease. It is associated with immunosuppression and shows a marked tendency to recur. We investigated a natural immunostimulant aimed to reduce recurrence. Method  A randomized controlled study was carried out including 261 patients allocated to surgical excision alone (control group; n = 122) and surgical excision plus postoperative immunostimulation for 30 days with a natural product (STET; study group; n = 139). Patients with HIV positivity were excluded. All patients gave fully informed consent. Results  The patients were followed for 6 months after surgery. Recurrence occurred in 7.2% (10/139) in the study group and in 27.1% (33/122) in the control group (P 
ISSN:1462-8910
1463-1318
DOI:10.1111/j.1463-1318.2009.01960.x