Boron Drug Delivery via Encapsulated Magnetic Nanocomposites: A New Approach for BNCT in Cancer Treatment

Ortho-carborane cages have been successfully attached to modified magnetic nanoparticles via catalytic azide-alkyne cycloadditions between 1-R-2-butyl-Ortho-C2B10H10(R=Me,3;Ph,4) and propargyl group-enriched magnetic nanoparticles. A loading amount of 9.83 mmol boron atom/g starch-matrixed magnetic...

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Bibliographic Details
Published in:Journal of nanomaterials 2010-01, Vol.2010 (1)
Main Authors: Zhu, Yinghuai, Lin, Yongxiang, Zhu, Yi Zhun, Lu, Jia, Maguire, John A., Hosmane, Narayan S.
Format: Article
Language:English
Subjects:
Boron
Brain
Brain cancer
Cages
Cancer
Cancer therapies
Charged particles
Circulatory system
Encapsulation
Magnetic fields
Nanocomposites
Nanomaterials
Nanoparticles
Polyamines
Studies
Tumors
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Summary:Ortho-carborane cages have been successfully attached to modified magnetic nanoparticles via catalytic azide-alkyne cycloadditions between 1-R-2-butyl-Ortho-C2B10H10(R=Me,3;Ph,4) and propargyl group-enriched magnetic nanoparticles. A loading amount of 9.83 mmol boron atom/g starch-matrixed magnetic nanoparticles has been reached. The resulting nanocomposites have been found to be highly tumor-targeted vehicles under the influence of an external magnetic field (1.14T), yielding a high boron concentration of 51.4 μg/g tumor and ratios of around 10 : 1 tumor to normal tissues.
ISSN:1687-4110
1687-4129
DOI:10.1155/2010/409320