Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer

Background and Objectives Simple methods to identify colorectal cancer patients at risk of recurrence are needed. This study aimed to determine if neutrophil‐to‐lymphocyte ratio (NLR) predicts survival in colorectal cancer patients. Methods Two‐hundred thirty patients diagnosed with colorectal cance...

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Bibliographic Details
Published in:Journal of surgical oncology 2005-09, Vol.91 (3), p.181-184
Main Authors: Walsh, S.R., Cook, E.J., Goulder, F., Justin, T.A., Keeling, N.J.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
colorectal cancer
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - immunology
Colorectal Neoplasms - mortality
Female
Humans
Inflammation - blood
Leukocyte Count
Lymphocytes
Male
Multivariate Analysis
Neutrophils
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Prospective Studies
Sensitivity and Specificity
Survival Rate
systemic inflammatory response
United Kingdom - epidemiology
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Summary:Background and Objectives Simple methods to identify colorectal cancer patients at risk of recurrence are needed. This study aimed to determine if neutrophil‐to‐lymphocyte ratio (NLR) predicts survival in colorectal cancer patients. Methods Two‐hundred thirty patients diagnosed with colorectal cancer over a two‐year period were identified from a prospectively maintained colorectal cancer database. NLR was calculated from pre‐operative full blood counts. In the case of patients who did not undergo surgery, the full blood count from their out‐patient visit was used. Known prognostic factors were recorded. Overall and cancer‐specific survival were calculated. Results Pre‐operative NLR greater than 5 correlated with overall and cancer‐specific survival in univariate analyses. NLR was not independent of Dukes stage. Conclusions Pre‐operative NLR may represent a simple method of identifying colorectal cancer patients with a poor prognosis pre‐operatively. J. Surg. Oncol. 2005;91:181–184. © 2005 Wiley‐Liss, Inc.
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.20329