Cytokine and cytokine receptor serum levels in adult bone sarcoma patients: Correlations with local tumor extent and prognosis

• Published in: Journal of surgical oncology 2003-11, Vol.84 (3), p.151-159
• Main Authors: Rutkowski, Piotr, Kamińska, Janina, Kowalska, Maria, Ruka, Wlodzimierz, Steffen, Jan
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biological and medical sciences; bone; Bone Neoplasms - blood; Bone Neoplasms - pathology; Chondrosarcoma - blood; Chondrosarcoma - pathology; cytokine; Cytokines - blood; Disease Progression; Diseases of the osteoarticular system; Female; Giant Cell Tumor of Bone - blood; Giant Cell Tumor of Bone - pathology; Humans; Male; Medical sciences; Middle Aged; Multivariate Analysis; Neoplasm Invasiveness; Osteosarcoma - blood; Osteosarcoma - pathology; Prognosis; Prospective Studies; Receptors, Cytokine - blood; sarcoma; Sarcoma - blood; Sarcoma - pathology; Sarcoma, Ewing - blood; Sarcoma, Ewing - pathology; Tumors of striated muscle and skeleton
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/jso.10305

Background and Objectives We analyzed the correlations between pretreatment serum levels of 11 cytokines and soluble cytokine receptors (interleukin 6 (IL‐6); interleukin 8 (IL‐8); interleukin 10 (IL‐10); vascular endothelial growth factor (VEGF); basic fibroblast growth factor (bFGF); macrophage colony‐stimulating factor (M‐CSF); granulocyte colony‐stimulating factor (G‐CSF); interleukin 1 receptor antagonist (IL‐1ra); sIL‐2Rα; tumor necrosis factor receptor I (TNF RI), and TNF RII) with clinico‐pathological features and survival of patients with bone sarcomas. Methods Altogether, 72 patients with bone sarcomas without distant metastases before treatment (26 osteosarcomas‐36%, 23 chondrosarcomas‐32%, 13 Ewing's sarcomas/PNET‐18%, 10 giant‐cell tumors‐14%), 22 patients with benign non‐inflammatory bone tumors and 50 age‐matched healthy controls were included into this prospective study. Results Median serum levels of 9/11 cytokines, with the exception of sIL‐2Rα and G‐CSF, were significantly higher in sarcoma patients than in controls. Median serum levels of IL‐6, IL‐8, IL‐1ra, TNF RI, and M‐CSF were significantly higher in patients with bone sarcoma as compared to patients with benign bone tumors. In 45.9% of sarcoma patients, six or more cytokines and cytokine receptors, including those that are involved in bone destruction (e.g., IL‐6 and IL‐8) and bone formation (e.g., IL‐1ra and TNFRI and TNFRII), were elevated in parallel. Serum levels of IL‐6, IL‐8, TNF RI, TNF RII, and VEGF correlated significantly with tumor size (