Increased excitability and metabolism in pilocarpine induced epileptic rats: Effect of Bacopa monnieri

We have evaluated the acetylcholine esterase and malate dehydrogenase activity in the muscle, epinephrine, norepinephrine, insulin and T3 content in the serum of epileptic rats. Acetylcholine esterase and malate dehydrogenase activity increased in the muscle and decreased in the heart of the epilept...

Full description

Saved in:
Bibliographic Details
Published in:Fitoterapia 2010-09, Vol.81 (6), p.546-551
Main Authors: Mathew, Jobin, Paul, Jes, Nandhu, M.S., Paulose, C.S.
Format: Article
Language:English
Subjects:
Bacopa monnieri
Bacoside-A
Carbamazepine
Epilepsy
Pilocarpine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have evaluated the acetylcholine esterase and malate dehydrogenase activity in the muscle, epinephrine, norepinephrine, insulin and T3 content in the serum of epileptic rats. Acetylcholine esterase and malate dehydrogenase activity increased in the muscle and decreased in the heart of the epileptic rats compared to control. Insulin and T3 content were increased significantly in the serum of the epileptic rats. Our results suggest that repetitive seizures resulted in increased metabolism and excitability in epileptic rats. Bacopa monnieri and Bacoside-A treatment prevents the occurrence of seizures there by reducing the impairment on peripheral nervous system. [Display omitted]
ISSN:0367-326X
DOI:10.1016/j.fitote.2010.01.017