Influence of seizures on lipids of homogenate and neuronal and glial nuclei of rat neocortex

Lipid composition of homogenate and neuronal and glial nuclei of the brain cortex of Wistar rats was studied under normal conditions and after seizures induced by injection of picrotoxin. Seizures increased contents of lysophosphatidylcholine, sphingomyelin, and total phospholipids in the homogenate...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2004-10, Vol.69 (10), p.1143-1147
Main Authors: Kulagina, T P, Shevchenko, N A, Arkhipov, V I
Format: Article
Language:English
Subjects:
Animals
Brain
Cell Nucleus - metabolism
Cell Nucleus - ultrastructure
Convulsants
DNA - metabolism
Fatty acids
Lipid Metabolism
Lipids
Lysophosphatidylcholines - metabolism
Male
Microscopy, Electron
Neocortex - metabolism
Neuroglia
Neuroglia - metabolism
Neurons
Neurons - metabolism
Nuclear Proteins - metabolism
Physiological aspects
Picrotoxin
Rats
Rattus
Rodents
Seizures - chemically induced
Seizures - metabolism
Sphingomyelins - metabolism
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Summary:Lipid composition of homogenate and neuronal and glial nuclei of the brain cortex of Wistar rats was studied under normal conditions and after seizures induced by injection of picrotoxin. Seizures increased contents of lysophosphatidylcholine, sphingomyelin, and total phospholipids in the homogenate. In neuronal nuclei contents of total phospholipids, sphingomyelin, phosphatidylcholine, and phosphatidylserine decreased, and contents of free fatty acids and lysophosphatidylcholine increased. In glial nuclei content of total phospholipids decreased and content of free fatty acids increased. The role of changes in the lipid composition of the neocortex cells during seizures and the involvement of lipid messengers in signal mechanisms are discussed.
ISSN:0006-2979
1608-3040
DOI:10.1023/B:BIRY.0000046889.60018.8c