Involvement of serum vascular endothelial growth factor family members in the development of obesity in mice and humans

Adipose tissue is highly vascularized implying that angiogenesis takes place in its expansion. The aim of this study was to compare the concentrations of members of the vascular endothelial growth factor (VEGF) family in obesity. Serum concentrations of VEGFs were analyzed in 15 lean (BMI 20.3±2.5 k...

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Bibliographic Details
Published in:The Journal of nutritional biochemistry 2010-08, Vol.21 (8), p.774-780
Main Authors: Gómez-Ambrosi, Javier, Catalán, Victoria, Rodríguez, Amaia, Ramírez, Beatriz, Silva, Camilo, Gil, María J., Salvador, Javier, Frühbeck, Gema
Format: Article
Language:English
Subjects:
Adipose tissue
Animals
Biological and medical sciences
Body Mass Index
Dietary Fats - administration & dosage
Enzyme-Linked Immunosorbent Assay
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
High-fat diet
Humans
Leptin
Leptin - administration & dosage
Male
Mice
ob/ob mice
Obesity
Obesity - blood
Vascular Endothelial Growth Factor A - blood
VEGF
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Citations: Items that cite this one
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Summary:Adipose tissue is highly vascularized implying that angiogenesis takes place in its expansion. The aim of this study was to compare the concentrations of members of the vascular endothelial growth factor (VEGF) family in obesity. Serum concentrations of VEGFs were analyzed in 15 lean (BMI 20.3±2.5 kg/m 2) and 24 obese (BMI 47.6±5.9 kg/m 2) volunteers. Obese patients showed significantly increased circulating VEGF-A (150±104 vs. 296±160 pg/ml; P
ISSN:0955-2863
1873-4847
DOI:10.1016/j.jnutbio.2009.05.004