Effect of vaccination with pneumococcal capsular polysaccharides conjugated to Haemophilus influenzae -derived protein D on nasopharyngeal carriage of Streptococcus pneumoniae and H. influenzae in children under 2 years of age

Abstract Following primary and booster vaccination with an 11-valent pneumococcall protein D conjugate vaccine there was a 42.8% (95% CI: −16.7 to 71.9, ns) reduction in the carriage of Streptococcus pneumoniae vaccine serotypes and a 42.6% (95% CI: 1.3–66.6) reduction in the carriage of Haemophilus...

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Bibliographic Details
Published in:Vaccine 2009-12, Vol.28 (1), p.71-78
Main Authors: Prymula, Roman, Kriz, Pavla, Kaliskova, Eva, Pascal, Thierry, Poolman, Jan, Schuerman, Lode
Format: Article
Language:English
Subjects:
Acute otitis media
Age
Allergy and Immunology
Bacterial Proteins - immunology
Carrier Proteins - immunology
Carrier State - immunology
Carrier State - prevention & control
Child, Preschool
DNA, Bacterial - isolation & purification
Double-Blind Method
Female
Haemophilus Infections - immunology
Haemophilus Infections - prevention & control
Haemophilus influenzae
Humans
Immunoglobulin D - immunology
Infant
Lipoproteins - immunology
Male
Nasopharyngeal carriage
Nasopharynx - microbiology
Otitis Media - microbiology
Otitis Media - prevention & control
Pneumococcal Infections - immunology
Pneumococcal Infections - prevention & control
Pneumococcal protein D conjugate vaccine
Pneumococcal Vaccines - immunology
Polysaccharides, Bacterial - immunology
Prospective Studies
Streptococcus pneumoniae
Vaccines, Conjugate - immunology
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Summary:Abstract Following primary and booster vaccination with an 11-valent pneumococcall protein D conjugate vaccine there was a 42.8% (95% CI: −16.7 to 71.9, ns) reduction in the carriage of Streptococcus pneumoniae vaccine serotypes and a 42.6% (95% CI: 1.3–66.6) reduction in the carriage of Haemophilus influenzae identified by standard microbiological techniques. When PCR and immunoblot assays were used to further improve specificity of non-typeable H. influenzae strain identification, carriage of H. influenzae was still reduced with 38.6% (95% CI: −6.3 to 64.6, ns). Reduction of acute otitis media (AOM) episodes preceded the impact on carriage. These data provide further support of the functional role of the protein D immunity.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2009.09.113