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Effect of vaccination with pneumococcal capsular polysaccharides conjugated to Haemophilus influenzae -derived protein D on nasopharyngeal carriage of Streptococcus pneumoniae and H. influenzae in children under 2 years of age

Abstract Following primary and booster vaccination with an 11-valent pneumococcall protein D conjugate vaccine there was a 42.8% (95% CI: −16.7 to 71.9, ns) reduction in the carriage of Streptococcus pneumoniae vaccine serotypes and a 42.6% (95% CI: 1.3–66.6) reduction in the carriage of Haemophilus...

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Published in:	Vaccine 2009-12, Vol.28 (1), p.71-78
Main Authors:	Prymula, Roman, Kriz, Pavla, Kaliskova, Eva, Pascal, Thierry, Poolman, Jan, Schuerman, Lode
Format:	Article
Language:	English
Subjects:	Acute otitis media Age Allergy and Immunology Bacterial Proteins - immunology Carrier Proteins - immunology Carrier State - immunology Carrier State - prevention & control Child, Preschool DNA, Bacterial - isolation & purification Double-Blind Method Female Haemophilus Infections - immunology Haemophilus Infections - prevention & control Haemophilus influenzae Humans Immunoglobulin D - immunology Infant Lipoproteins - immunology Male Nasopharyngeal carriage Nasopharynx - microbiology Otitis Media - microbiology Otitis Media - prevention & control Pneumococcal Infections - immunology Pneumococcal Infections - prevention & control Pneumococcal protein D conjugate vaccine Pneumococcal Vaccines - immunology Polysaccharides, Bacterial - immunology Prospective Studies Streptococcus pneumoniae Vaccines, Conjugate - immunology
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creator	Prymula, Roman Kriz, Pavla Kaliskova, Eva Pascal, Thierry Poolman, Jan Schuerman, Lode
description	Abstract Following primary and booster vaccination with an 11-valent pneumococcall protein D conjugate vaccine there was a 42.8% (95% CI: −16.7 to 71.9, ns) reduction in the carriage of Streptococcus pneumoniae vaccine serotypes and a 42.6% (95% CI: 1.3–66.6) reduction in the carriage of Haemophilus influenzae identified by standard microbiological techniques. When PCR and immunoblot assays were used to further improve specificity of non-typeable H. influenzae strain identification, carriage of H. influenzae was still reduced with 38.6% (95% CI: −6.3 to 64.6, ns). Reduction of acute otitis media (AOM) episodes preceded the impact on carriage. These data provide further support of the functional role of the protein D immunity.
doi_str_mv	10.1016/j.vaccine.2009.09.113
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subjects	Acute otitis media Age Allergy and Immunology Bacterial Proteins - immunology Carrier Proteins - immunology Carrier State - immunology Carrier State - prevention & control Child, Preschool DNA, Bacterial - isolation & purification Double-Blind Method Female Haemophilus Infections - immunology Haemophilus Infections - prevention & control Haemophilus influenzae Humans Immunoglobulin D - immunology Infant Lipoproteins - immunology Male Nasopharyngeal carriage Nasopharynx - microbiology Otitis Media - microbiology Otitis Media - prevention & control Pneumococcal Infections - immunology Pneumococcal Infections - prevention & control Pneumococcal protein D conjugate vaccine Pneumococcal Vaccines - immunology Polysaccharides, Bacterial - immunology Prospective Studies Streptococcus pneumoniae Vaccines, Conjugate - immunology
title	Effect of vaccination with pneumococcal capsular polysaccharides conjugated to Haemophilus influenzae -derived protein D on nasopharyngeal carriage of Streptococcus pneumoniae and H. influenzae in children under 2 years of age
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