Vitamin D supplementation suppresses age-induced bone turnover in older women who are vitamin D deficient

There is a lack of evidence that improving vitamin D status, without changing calcium intake, has a positive effect on bone turnover as indicated by bone marker changes. The objective was to measure the effect of vitamin D supplementation, in vitamin D deficient women (25(OH)D concentration 20 years...

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Bibliographic Details
Published in:Journal of steroid biochemistry and molecular biology 2010-07, Vol.121 (1), p.293-296
Main Authors: von Hurst, P.R., Stonehouse, W., Kruger, M.C., Coad, J.
Format: Article
Language:English
Subjects:
Adult
Aging
Biological and medical sciences
Bone and Bones - drug effects
Bone and Bones - metabolism
Bone Density
Bone markers
Bone Resorption
Bone turnover
Collagen Type I - metabolism
Dietary Supplements
Female
Fundamental and applied biological sciences. Psychology
Humans
Middle Aged
Osteocalcin - metabolism
Osteoclasts - drug effects
Peptides - metabolism
Vertebrates: endocrinology
Vertebrates: reproduction
Vitamin D
Vitamin D - therapeutic use
Vitamin D Deficiency - metabolism
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Summary:There is a lack of evidence that improving vitamin D status, without changing calcium intake, has a positive effect on bone turnover as indicated by bone marker changes. The objective was to measure the effect of vitamin D supplementation, in vitamin D deficient women (25(OH)D concentration 20 years. Subjects were stratified by age and menopausal status. Median (25th, 75th percentile) serum 25(OH)D increased significantly from 21 (11, 40) to 75 (55, 84) nmol/L with supplementation. In women >49 years or postmenopausal ( n = 26), who were not supplemented ( n = 13), CTX and OC levels increased ( P = 0.001, P = 0.004 respectively), indicating an increased rate of bone turnover. With supplementation CTX decreased ( P = 0.012) and there was no significant change in OC. In women who were under 49 years and premenopausal ( n = 55; 29 supplemented), there was no significant response to supplementation in either CTX or OC. We conclude that correcting vitamin D deficiency in older women suppresses the age-induced increase in bone turnover and reduces bone resorption which would normally be exacerbated in conditions of low serum 25(OH)D.
ISSN:0960-0760
1879-1220
DOI:10.1016/j.jsbmb.2010.03.054