Epidemiological serosurvey of Hepatitis B in China—Declining HBV prevalence due to Hepatitis B vaccination

Abstract Objective To determine the prevalence of hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core anti-body (anti-HBc) in a representative population in China 14 years after introduction of hepatitis B vaccination of infants. Methods National serosu...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2009-11, Vol.27 (47), p.6550-6557
Main Authors: Liang, Xiaofeng, Bi, Shengli, Yang, Weizhong, Wang, Longde, Cui, Gang, Cui, Fuqiang, Zhang, Yong, Liu, Jianhua, Gong, Xiaohong, Chen, Yuansheng, Wang, Fuzhen, Zheng, Hui, Wang, Feng, Guo, Jing, Jia, Zhiyuan, Ma, Jingchen, Wang, Huaqing, Luo, Huiming, Li, Li, Jin, Shuigao, Hadler, Stephen C, Wang, Yu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Distribution
Allergy and Immunology
Applied microbiology
Biological and medical sciences
Child
Child, Preschool
China - epidemiology
Female
Fundamental and applied biological sciences. Psychology
Hepatitis
Hepatitis B
Hepatitis B - epidemiology
Hepatitis B - prevention & control
Hepatitis B Core Antigens - blood
Hepatitis B Surface Antigens - blood
Hepatitis B Vaccines - administration & dosage
Hepatitis B virus
Human viral diseases
Humans
Immunization
Immunization Programs
Infant
Infants
Infectious diseases
Laboratories
Logistic Models
Male
Medical sciences
Microbiology
Middle Aged
Minority & ethnic groups
Miscellaneous
Multivariate Analysis
Prevalence
Seroepidemiologic Studies
Serosurvey
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Viral hepatitis
Virology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Objective To determine the prevalence of hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core anti-body (anti-HBc) in a representative population in China 14 years after introduction of hepatitis B vaccination of infants. Methods National serosurvey, with participants selected by multi-stage random sampling. Demographics and hepatitis B vaccination history collected by questionnaire and review of vaccination records, and serum tested for HBsAg, antibody to anti-HBc and anti-HBs by ELISA. Findings The weighted prevalences of HBsAg, anti-HBs and anti-HBc for Chinese population aged 1–59 years were 7.2%, 50.1%, 34.1%, respectively. HBsAg prevalence was greatly diminished among those age
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2009.08.048