Brainstem encephalitis following influenza vaccination: Favorable response to steroid treatment

Abstract We report a 44-year-old man presenting with left hemiparesis following influenza vaccination. The neuroimaging studies showed a large, contrast-enhancing brainstem lesion and multiple punctate lesions suggesting microhaemorrhages in both cerebral hemispheres. The patient showed a remarkable...

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Bibliographic Details
Published in:Vaccine 2009-12, Vol.27 (52), p.7253-7256
Main Authors: Tuerkoolu, Recai, Tuezuen, Erdem
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Applied microbiology
Biological and medical sciences
Brain Stem - pathology
Brainstem encephalitis
Encephalitis - drug therapy
Encephalitis - etiology
Fundamental and applied biological sciences. Psychology
Humans
Influenza
Influenza Vaccines - adverse effects
Lesions
Magnetic Resonance Imaging
Male
Medical treatment
Microbiology
Mortality
Paresis - drug therapy
Paresis - etiology
Steroids
Steroids - therapeutic use
Vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:Abstract We report a 44-year-old man presenting with left hemiparesis following influenza vaccination. The neuroimaging studies showed a large, contrast-enhancing brainstem lesion and multiple punctate lesions suggesting microhaemorrhages in both cerebral hemispheres. The patient showed a remarkable response to high dose steroid treatment. Detailed diagnostic studies failed to yield any results supporting inflammatory/demyelinating diseases, suggesting that influenza vaccination might have been associated with the clinical findings. Our case implies that vaccination might be related with a wide range of clinical syndromes, including brainstem encephalitis.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2009.08.111