Persistence of vaccine immunity against hepatitis B virus and response to revaccination in vertically HIV-infected adolescents on HAART

• Published in: Vaccine 2010-02, Vol.28 (6), p.1606-1612
• Main Authors: Pessoa, Silvana D, Miyamoto, Maristela, Ono, Erika, Gouvêa, Aída F.T.B, de Moraes-Pinto, Maria Isabel, Succi, Regina C.M
• Format: Article
• Language: English
• Subjects: Adolescent; Adolescents; Allergy and Immunology; Antigens; Antiretroviral drugs; Antiretroviral Therapy, Highly Active; Applied microbiology; Biological and medical sciences; CD38; CD4-CD8 Ratio; CD8-Positive T-Lymphocytes - immunology; Child; Fundamental and applied biological sciences. Psychology; Hepatitis; Hepatitis B Antibodies - blood; Hepatitis B vaccine; Hepatitis B Vaccines - immunology; Hepatitis B virus; Hepatitis B virus - immunology; HIV; HIV - isolation & purification; HIV Infections - drug therapy; HIV Infections - transmission; Human immunodeficiency virus; Human viral diseases; Humans; Immune response; Immune system; Immunization; Immunization, Secondary; Immunologic Memory; Infectious Disease Transmission, Vertical; Infectious diseases; Lymphocytes; Medical sciences; Microbiology; Miscellaneous; Time Factors; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; Virology; Young Adult
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2009.11.045

Abstract Humoral immune response to vaccine antigens is known to be reduced in perinatally HIV-infected children. Lymphocyte immunophenotyping, humoral immunity to hepatitis B after primary immunization and response to revaccination were evaluated in 40 HIV-infected adolescents on HAART and 23 healthy age-matched controls. Anti-HBs antibody levels ≥10 mIU/mL were found in 18/40 (40.5%) of the HIV-infected adolescents and 18/23 (78.3%) of the HIV-negative adolescents from Control group. Adolescents of HIV group with anti-HBs ≥ 10 mIU/mL presented a higher CD4+ T cell percentage, higher naïve and central memory CD8+ T cell percentages and lower immune activation markers. After revaccination, 12/18 (66.7%) adolescents of HIV group responded. Those adolescents who did not respond to revaccination presented a lower CD4+ T cell percentage, higher immune activation markers and more frequently detectable HIV viral load. We concluded that lower immune activation, higher CD4+ T cell percentage and better control of HIV replication may be associated with hepatitis B vaccine response.