Antiproliferative effects of inhibitors of polyamine synthesis in tumors of neural origin

• Published in: Journal of pharmaceutical sciences 1980-06, Vol.69 (6), p.733-735
• Main Authors: Chapman, Sharon K., Glant, Susan K.
• Format: Article
• Language: English
• Subjects: Animals; Antineoplastic Agents; Antitumor activity-inhibition of polyamine synthesis; Antitumor activity—inhibition of polyamine synthesis, in vitro testing of ornithine carboxylase activity; Cadaverine - pharmacology; Cell Division - drug effects; Cell Line; Diamines - pharmacology; effects of inhibitors on tumor cell growth; Glioma - drug therapy; Glioma - metabolism; in vitro testing; in vitro testing of ornithine carboxylase activity; Mice; Neoplasms, Experimental - drug therapy; Neuroblastoma - drug therapy; Neuroblastoma - metabolism; Ornithine carboxylase activity-inhibition of polyamine synthesis; Ornithine carboxylase activity—inhibition of polyamine synthesis, effects of inhibitors on tumor cell growth, in vitro testing; Ornithine Decarboxylase Inhibitors; Polyamines - biosynthesis; Polyamines-inhibition of synthesis; Polyamines—inhibition of synthesis, effects of inhibitors on tumor cell growth, in vitro testing; Rats
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.2600690635

The antiproliferative properties of inhibitors of polyamine synthesis were evaluated in cultured neuroblastoma and glioma cells. The diamines (1,3-propanediamine, 1,5-pentanediamine, and 1,6-hexanediamine) dramatically decreased neuroblastoma replication and inhibited the rate-limiting enzyme, ornithine decarboxylase. Glioma cells were less sensitive to the diamines in spite of significant drug-induced decreases in enzyme activity. The fact that ornithine decarboxylase was inhibited in both cell lines with different effects on proliferation suggests that the activity of other enzymes in polyamine biosynthesis may be altered selectively by these inhibitors.