Genetic and biological characterization of avian influenza H5N1 viruses isolated from wild birds and poultry in Western Siberia

Three viruses included in the study were isolated from dead birds (A/duck/Omsk/1822/2006, A/chicken/Reshoty/02/2006, and A/duck/Tuva/01/2006), whereas the virus A/common gull/Chany/P/2006 was isolated from an apparently healthy gull during outbreaks of highly pathogenic avian influenza in Russia in...

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Bibliographic Details
Published in:Archives of virology 2010-07, Vol.155 (7), p.1145-1150
Main Authors: Sharshov, Kirill, Romanovskaya, Alesia, Uzhachenko, Roman, Durymanov, Alexander, Zaykovskaya, Anna, Kurskaya, Olga, Ilinykh, Philipp, Silko, Nikita, Kulak, Mikhail, Alekseev, Alexander, Zolotykh, Sergei, Shestopalov, Alexander, Drozdov, Iliya
Format: Article
Language:English
Subjects:
Adaptation
Amino Acid Sequence
Amino Acid Substitution
Animals
Aves
Avian flu
Biomedical and Life Sciences
Biomedicine
Bird migration
Birds
Brief Report
Chickens
Eggs
Embryos
Epidemics
Fatalities
Infections
Infectious Diseases
Influenza A Virus, H5N1 Subtype - classification
Influenza A Virus, H5N1 Subtype - genetics
Influenza A Virus, H5N1 Subtype - pathogenicity
Influenza in Birds - epidemiology
Influenza in Birds - virology
Medical Microbiology
Mice
Mice, Inbred BALB C
Pathogens
Phylogeny
Poultry
RNA polymerase
Siberia - epidemiology
Specific Pathogen-Free Organisms
Viral Proteins - genetics
Viral Proteins - metabolism
Virology
Virulence
Viruses
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Summary:Three viruses included in the study were isolated from dead birds (A/duck/Omsk/1822/2006, A/chicken/Reshoty/02/2006, and A/duck/Tuva/01/2006), whereas the virus A/common gull/Chany/P/2006 was isolated from an apparently healthy gull during outbreaks of highly pathogenic avian influenza in Russia in 2006. The intravenous pathogenicity index (IVPI) of viruses A/duck/Omsk/1822/2006, A/chicken/Reshoty/02/2006, and A/duck/Tuva/01/2006 ranged from 2.7 to 3.0, while the virus A/common gull/Chany/P/2006 had a markedly lower IVPI of 1.7. The virus A/common gull/Chany/P/2006 had a unique pattern of six amino acid substitutions in the regions of viral proteins crucial for virulence of H5N1 viruses. We hypothesize that these substitutions may affect the pathogenicity of A/common gull/Chany/P/2006.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-010-0676-2